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    nas-37 Zinc metalloproteinase nas-37 [ Caenorhabditis elegans ]

    Gene ID: 181208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nas-37
    Official Full Name
    Zinc metalloproteinase nas-37
    Primary source
    WormBase:WBGene00003553
    Locus tag
    CELE_C17G1.6
    See related
    AllianceGenome:WB:WBGene00003553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables metalloendopeptidase activity. Involved in collagen and cuticulin-based cuticle development and ecdysis, collagen and cuticulin-based cuticle. Located in extracellular region. Is expressed in several structures, including cuticle; epithelial cell; intestine; rectum; and reproductive system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nas-37 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    18
    Sequence:
    Chromosome: X; NC_003284.9 (9944844..9949063, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Cysteine synthase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The astacin metalloprotease moulting enzyme NAS-36 is required for normal cuticle ecdysis in free-living and parasitic nematodes. Stepek G, et al. Parasitology, 2011 Feb. PMID 20800010
    2. IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans. Yang HC, et al. J Mol Med (Berl), 2019 Mar. PMID 30661088, Free PMC Article
    3. A potential role for fatty acid biosynthesis genes during molting and cuticle formation in Caenorhabditis elegans. Li Y, et al. BMB Rep, 2011 Apr. PMID 21524356
    4. A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans. Davis MW, et al. Development, 2004 Dec. PMID 15539494
    5. SnAvi--a new tandem tag for high-affinity protein-complex purification. Schäffer U, et al. Nucleic Acids Res, 2010 Apr. PMID 20047968, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nas37 mediates ecdysis in Caenorhabditis elegans
      Title: A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen and cuticulin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in molting cycle, collagen and cuticulin-based cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in molting cycle, collagen and cuticulin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zinc metalloproteinase nas-37
    NP_001024413.1
    • Confirmed by transcript evidence
    NP_001024414.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9944844..9949063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029243.7 → NP_001024414.1  Zinc metalloproteinase nas-37 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93243
      Conserved Domains (4) summary
      smart00042
      Location:370 → 455
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00209
      Location:499 → 546
      TSP1; Thrombospondin type 1 repeats
      cd04280
      Location:126 → 306
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:122 → 309
      Astacin; Astacin (Peptidase family M12A)

    2. NM_001029242.7 → NP_001024413.1  Zinc metalloproteinase nas-37 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5CZ39, Q93243
      Conserved Domains (4) summary
      smart00042
      Location:370 → 455
      CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
      smart00209
      Location:579 → 626
      TSP1; Thrombospondin type 1 repeats
      cd04280
      Location:126 → 306
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:122 → 309
      Astacin; Astacin (Peptidase family M12A)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93243.2

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