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    snai-1 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snai-1
    Official Full Name
    C2H2-type domain-containing protein
    Primary source
    WormBase:WBGene00019299
    Locus tag
    CELE_K02D7.2
    See related
    AllianceGenome:WB:WBGene00019299
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in PHAL; PHAR; PHBL; PHBR; and amphid neurons. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to several human genes including SNAI1 (snail family transcriptional repressor 1) and SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snai-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (311484..313715, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Purine nucleoside phosphorylase Neighboring gene Sugar transporter SWEET1 Neighboring gene ncRNA Neighboring gene Microsomal triglyceride transfer protein homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Jin Y, et al. Cancer Lett, 2015 Jun 28. PMID 25827072, Free PMC Article
    2. The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors. Reece-Hoyes JS, et al. Nucleic Acids Res, 2009 Jun. PMID 19372275, Free PMC Article
    3. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein
    NP_499902.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      311484..313715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067501.4 → NP_499902.2  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499902.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45103
      Conserved Domains (3) summary
      COG5048
      Location:98 → 155
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:98 → 118
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:138 → 163
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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