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    cpi-1 Cystatin cpi-1 [ Caenorhabditis elegans ]

    Gene ID: 177372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cpi-1
    Official Full Name
    Cystatin cpi-1
    Primary source
    WormBase:WBGene00000535
    Locus tag
    CELE_K08B4.6
    See related
    AllianceGenome:WB:WBGene00000535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cysteine-type endopeptidase inhibitor activity. Predicted to be active in cytoplasm; extracellular space; and vesicle. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy; age related macular degeneration 11; and ectodermal dysplasia 15. Orthologous to several human genes including CST3 (cystatin C); CST4 (cystatin S); and CST1 (cystatin SN). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cpi-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (6092603..6093680, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cystatin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Suppressor of hairless protein homolog Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parasite-specific immunomodulatory functions of filarial cystatin. Schierack P, et al. Infect Immun, 2003 May. PMID 12704112, Free PMC Article
    2. Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins. Phiri AM, et al. Parasitology, 2014 Feb. PMID 24001183
    3. Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship. Gregory WF, et al. Int J Biochem Cell Biol, 2008. PMID 18249028
    4. Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP. Murray J, et al. Mol Biochem Parasitol, 2005 Feb. PMID 15664654
    5. Gene expression profiling studies on Caenorhabditis elegans dystrophin mutants dys-1(cx-35) and dys-1(cx18). Towers PR, et al. Genomics, 2006 Nov. PMID 16962739

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Wild-type Caenorhabditis elegans deploy cystatins CPI-1 and CPI-2 to resist cysteine proteinase (CP) attack.
      Title: Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cystatin cpi-1
    NP_500915.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6092603..6093680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068514.6 → NP_500915.1  Cystatin cpi-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDZ9
      Conserved Domains (1) summary
      smart00043
      Location:20 → 124
      CY; Cystatin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDZ9.1

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