cah-4 Alpha-carbonic anhydrase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cah-4
Official Full Name: Alpha-carbonic anhydrase domain-containing protein
Primary source: WormBase:WBGene00000282
Locus tag: CELE_R01E6.3
See related: AllianceGenome:WB:WBGene00000282
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables carbonate dehydratase activity. Involved in small molecule metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including body wall musculature; enteric muscle; excretory cell; rectal muscle; and somatic nervous system. Orthologous to several human genes including CA1 (carbonic anhydrase 1); CA13 (carbonic anhydrase 13); and CA3 (carbonic anhydrase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cah-4 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (13542574..13544599)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genes possibly encoding beta-CAs were revealed by in silico analysis of the C. elegans genome.[Carbonic anhydrase]
Title: Molecular and biochemical analysis of the beta class carbonic anhydrases in Caenorhabditis elegans.
Both methazolamide and dichlorphenamide were shown to interact with CAH-4.
Title: Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.
The gene cah-4 encodes two putative alpha carbonic anhydrases (CAH-4a and CAH-4b), one of which was five-fold up regulated in an alkaline environment - CAH-4b.
Title: External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R01E6.3 (e-PCR)
- UniSTS:313267

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in small molecule metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Alpha-carbonic anhydrase domain-containing protein

NP_510264.1

Confirmed by transcript evidence

NP_510265.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

13542574..13544599

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077863.9 → NP_510264.1 Alpha-carbonic anhydrase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510264.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8WQD8

Conserved Domains (1) summary

cd00326
Location:5 → 230

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
NM_077864.6 → NP_510265.1 Alpha-carbonic anhydrase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510265.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21614

Conserved Domains (1) summary

cd00326
Location:50 → 275

alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...