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    Y47G6A.5 Tyrosine-protein kinase [ Caenorhabditis elegans ]

    Gene ID: 189992, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Y47G6A.5
    Official Full Name
    Tyrosine-protein kinase
    Primary source
    WormBase:WBGene00021635
    Locus tag
    CELE_Y47G6A.5
    See related
    AllianceGenome:WB:WBGene00021635
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y47G6A.5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (3533885..3539580)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Peptidase M14 carboxypeptidase A domain-containing protein;ShKT domain-containing protein Neighboring gene 40S ribosomal protein S19-binding protein 1 Neighboring gene ncRNA Neighboring gene Poly(U)-binding-splicing factor rnp-6 Neighboring gene RNA interference defective protein 10 Neighboring gene DeHydrogenases, Short chain Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tyrosine-protein kinase
    NP_491175.2
    • Confirmed by transcript evidence
    NP_871806.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3533885..3539580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058774.5 → NP_491175.2  Tyrosine-protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491175.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N3S5
      Conserved Domains (4) summary
      smart00219
      Location:328 → 600
      TyrKc; Tyrosine kinase, catalytic domain
      cd00192
      Location:332 → 601
      PTKc; Catalytic domain of Protein Tyrosine Kinases
      cl15255
      Location:201 → 305
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:151 → 194
      SH3; Src Homology 3 domain superfamily

    2. NM_182006.5 → NP_871806.1  Tyrosine-protein kinase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IAA6
      Conserved Domains (4) summary
      smart00219
      Location:284 → 556
      TyrKc; Tyrosine kinase, catalytic domain
      cd00192
      Location:288 → 557
      PTKc; Catalytic domain of Protein Tyrosine Kinases
      cl15255
      Location:157 → 261
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:107 → 150
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version

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