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    ceh-88 Homeobox domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178514, updated on 4-Jan-2025

    Summary

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    Official Symbol
    ceh-88
    Official Full Name
    Homeobox domain-containing protein
    Primary source
    WormBase:WBGene00008195
    Locus tag
    CELE_C49C3.5
    See related
    AllianceGenome:WB:WBGene00008195
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including anal depressor muscle; coelomocyte; excretory cell; hypodermis; and nervous system. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See ceh-88 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (17329188..17330737)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Coiled-coil domain-containing protein 176

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique homeobox codes delineate all the neuron classes of C. elegans. Reilly MB, et al. Nature, 2020 Aug. PMID 32814896, Free PMC Article
    2. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    4. Transcriptional regulation. Okkema PG, et al. WormBook, 2005 Dec 23. PMID 18050428, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein
    NP_503081.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17329188..17330737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070680.3 → NP_503081.2  Homeobox domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503081.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUG3
      Conserved Domains (1) summary
      smart00389
      Location:81 → 135
      HOX; Homeodomain
    Nucleotide Protein
    Heading Accession and Version

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