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    Y49E10.4 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176664, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y49E10.4
    Official Full Name
    Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00013030
    Locus tag
    CELE_Y49E10.4
    See related
    AllianceGenome:WB:WBGene00013030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-disulfide reductase activity. Predicted to be involved in response to endoplasmic reticulum stress. Predicted to be active in endoplasmic reticulum. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y49E10.4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (12379000..12380588, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serine/threonine-protein phosphatase 4 catalytic subunit 2 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin domain-containing protein
    NP_499613.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12379000..12380588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067212.8 → NP_499613.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XTU8
      Conserved Domains (2) summary
      cd02983
      Location:269 → 405
      P5_C; P5 family, C-terminal redox inactive TRX-like domain; P5 is a protein disulfide isomerase (PDI)-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is ...
      cd03001
      Location:26 → 127
      PDI_a_P5; PDIa family, P5 subfamily; composed of eukaryotic proteins similar to human P5, a PDI-related protein with a domain structure of aa'b (where a and a' are redox active TRX domains and b is a redox inactive TRX-like domain). Like PDI, P5 is located in the ...
    Nucleotide Protein
    Heading Accession and Version

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