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    rpt-4 putative 26S proteasome regulatory subunit 10B [ Caenorhabditis elegans ]

    Gene ID: 173384, updated on 9-Dec-2024

    Summary

    Official Symbol
    rpt-4
    Official Full Name
    putative 26S proteasome regulatory subunit 10B
    Primary source
    WormBase:WBGene00004504
    Locus tag
    CELE_F23F1.8
    See related
    AllianceGenome:WB:WBGene00004504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of protein stability. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cytosolic proteasome complex and proteasome regulatory particle, base subcomplex. Is expressed in nervous system and pharynx. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See rpt-4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (42207..46216, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Saposin B-type domain-containing protein Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Nuclear transcription factor Y subunit nfyc-1 Neighboring gene RNA polymerase I associated factor, A49-like protein Neighboring gene Nucleolus and neural progenitor protein-like N-terminal domain-containing protein Neighboring gene Serine palmitoyltransferase 1 Neighboring gene Trehalase

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    putative 26S proteasome regulatory subunit 10B
    NP_001022113.1
    • Confirmed by transcript evidence
    NP_001022114.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      42207..46216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026942.5NP_001022113.1  putative 26S proteasome regulatory subunit 10B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022113.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17071, Q5F4U7
      Conserved Domains (2) summary
      COG1222
      Location:21404
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:188320
      AAA; ATPase family associated with various cellular activities (AAA)
    2. NM_001026943.5NP_001022114.1  putative 26S proteasome regulatory subunit 10B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022114.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O17071
      Conserved Domains (2) summary
      COG1222
      Location:13396
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:180312
      AAA; ATPase family associated with various cellular activities (AAA)