egl-9 Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-9
Official Full Name: Hypoxia-inducible factor prolyl hydroxylase
Primary source: WormBase:WBGene00001178
Locus tag: CELE_F22E12.4
See related: AllianceGenome:WB:WBGene00001178
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables peptidyl-proline 4-dioxygenase activity. Involved in regulation of protein localization and response to hypoxia. Located in dendrite and nucleus. Is expressed in ventral nerve cord and vulval precursor cell. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to several human genes including EGLN1 (egl-9 family hypoxia inducible factor 1) and EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egl-9 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (10468517..10476915)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
Title: Hypoxic response regulators RHY-1 and EGL-9/PHD promote longevity through a VHL-1-independent transcriptional response.
study demonstrated that loss of egl-9, a negative regulator of HIF, confers HIF-dependent enhanced susceptibility to S. aureus while increasing resistance to Pseudomonas aeruginosa
Title: EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.
These data support a model in which SWAN-1, MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 fast killing.
Title: C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
Data show that EGL-9 inhibits HIF-1 transcriptional activity via a pathway that has little or no requirement for hydroxylase activity or for the EGL-9 MYND domain.
Title: Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F22E12.4 (e-PCR)
- UniSTS:307527

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables hypoxia-inducible factor-proline dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables peptidyl-proline 4-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-proline dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hypoxia-inducible factor prolyl hydroxylase

NP_001023833.1

Partially confirmed by transcript evidence

NP_001023834.1

Confirmed by transcript evidence

NP_001041105.1

Confirmed by transcript evidence

NP_001359645.1

Confirmed by transcript evidence

NP_741621.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10468517..10476915

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028663.6 → NP_001023834.1 Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023834.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBV0

Conserved Domains (2) summary

smart00702
Location:393 → 565

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam01753
Location:39 → 79

zf-MYND; MYND finger
NM_171533.7 → NP_741621.1 Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741621.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBV0, G5ECV8, G5EE79, G5EEP8, Q56W01

Conserved Domains (2) summary

smart00702
Location:393 → 565

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

pfam01753
Location:39 → 79

zf-MYND; MYND finger
NM_001373098.1 → NP_001359645.1 Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

pfam01753
Location:39 → 79

zf-MYND; MYND finger
NM_001047640.4 → NP_001041105.1 Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041105.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBV0

Conserved Domains (1) summary

smart00702
Location:317 → 489

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
NM_001028662.4 → NP_001023833.1 Hypoxia-inducible factor prolyl hydroxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023833.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EBV0

Conserved Domains (1) summary

smart00702
Location:135 → 307

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues