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    rec-8 Meiotic recombination protein rec-8 [ Caenorhabditis elegans ]

    Gene ID: 178295, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rec-8
    Official Full Name
    Meiotic recombination protein rec-8
    Primary source
    WormBase:WBGene00004333
    Locus tag
    CELE_W02A2.6
    See related
    AllianceGenome:WB:WBGene00004333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity and damaged DNA binding activity. Involved in several processes, including meiotic chromosome segregation; meiotic sister chromatid cohesion; and regulation of centriole-centriole cohesion. Located in chromatin; nuclear lumen; and spindle. Is expressed in embryonic cell; germ line; and gonad. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rec-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (13349122..13353193, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Plasma membrane proteolipid 3 Neighboring gene Uncharacterized protein Neighboring gene Zinc finger protein mex-5 Neighboring gene NT-3;Transposase;Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The consequences of tetraploidy on Caenorhabditis elegans physiology and sensitivity to chemotherapeutics. Misare KR, et al. Sci Rep, 2023 Oct 23. PMID 37872247, Free PMC Article
    2. Autosomal Trisomy and Triploidy Are Corrected During Female Meiosis in Caenorhabditis elegans. Vargas E, et al. Genetics, 2017 Nov. PMID 28882988, Free PMC Article
    3. Quantitative cytogenetics reveals molecular stoichiometry and longitudinal organization of meiotic chromosome axes and loops. Woglar A, et al. PLoS Biol, 2020 Aug. PMID 32813728, Free PMC Article
    4. Manipulation of Ploidy in Caenorhabditis elegans. Clarke EK, et al. J Vis Exp, 2018 Mar 15. PMID 29608173, Free PMC Article
    5. The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis. Rogers E, et al. J Cell Biol, 2002 Apr 15. PMID 11940606, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables damaged DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of centriole-centriole cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptonemal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cohesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in meiotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Meiotic recombination protein rec-8
    NP_001255727.1
    • Confirmed by transcript evidence
    NP_001255728.1
    • Confirmed by transcript evidence
    NP_001255729.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13349122..13353193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268798.3 → NP_001255727.1  Meiotic recombination protein rec-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E5QCH7, E5QCH8, Q9XUB3
      Conserved Domains (1) summary
      pfam04825
      Location:1 → 87
      Rad21_Rec8_N; N terminus of Rad21 / Rec8 like protein

    2. NM_001268799.3 → NP_001255728.1  Meiotic recombination protein rec-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255728.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUB3
      Conserved Domains (1) summary
      PRK14960
      Location:45 → 287
      PRK14960; DNA polymerase III subunits gamma and tau; Provisional

    3. NM_001268800.3 → NP_001255729.1  Meiotic recombination protein rec-8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255729.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUB3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUB3.1

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