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    pgl-3 Guanyl-specific ribonuclease pgl-3 [ Caenorhabditis elegans ]

    Gene ID: 178867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pgl-3
    Official Full Name
    Guanyl-specific ribonuclease pgl-3
    Primary source
    WormBase:WBGene00003994
    Locus tag
    CELE_C18G1.4
    See related
    AllianceGenome:WB:WBGene00003994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA endonuclease activity and identical protein binding activity. Located in P granule. Is expressed in Psub1 and germ line. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pgl-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (4755979..4758587)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Histone H1.4 Neighboring gene ncRNA Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog;Glyco_trans_2-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient production of monoclonal antibodies recognizing specific structures in Caenorhabditis elegans embryos using an antigen subtraction method. Takeda K, et al. Genes Cells, 2008 Jul. PMID 18498356
    2. Salt-Dependent Rheology and Surface Tension of Protein Condensates Using Optical Traps. Jawerth LM, et al. Phys Rev Lett, 2018 Dec 21. PMID 30608810
    3. The P granule antibody KT3 recognizes epitopes in both PGL-1 and PGL-3. Danlasky BM, et al. MicroPubl Biol, 2024. PMID 38440332, Free PMC Article
    4. PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans. Hanazawa M, et al. J Cell Biol, 2011 Mar 21. PMID 21402787, Free PMC Article
    5. Polar Positioning of Phase-Separated Liquid Compartments in Cells Regulated by an mRNA Competition Mechanism. Saha S, et al. Cell, 2016 Sep 8. PMID 27594427, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study demonstrates that germ-granule components, PGL-1 and PGL-3, can serve as negative regulators of apoptosis not only in the germline but also in the soma in C. elegans.
      Title: Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.
    2. PGL-1 and PGL-3 control germline apoptosis in C. elegans.
      Title: Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.
    3. we demonstrated that mutations in C. elegans epg-11 cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known as PGL granules, from somatic cells during embryogenesis
      Title: Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.
    4. Data show that the PGL proteins PGL-1 and PGL-3 serve as the scaffold for germ granule formation in Caenorhabditis elegans.
      Title: PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribonuclease T1 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Guanyl-specific ribonuclease pgl-3
    NP_504278.1
    • Confirmed by transcript evidence
    NP_504279.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4755979..4758587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071878.5 → NP_504279.1  Guanyl-specific ribonuclease pgl-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBV6

    2. NM_071877.7 → NP_504278.1  Guanyl-specific ribonuclease pgl-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504278.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBV6, Q965J2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBV6.1

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