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    clc-19 Transmembrane protein 225 [ Caenorhabditis elegans ]

    Gene ID: 188845, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clc-19
    Official Full Name
    Transmembrane protein 225
    Primary source
    WormBase:WBGene00020760
    Locus tag
    CELE_T24C4.4
    See related
    AllianceGenome:WB:WBGene00020760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clc-19 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (872621..873566, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ZSWIM3 N-terminal domain-containing protein Neighboring gene Protein DPCD Neighboring gene DUF2975 domain-containing protein Neighboring gene DNA primase Neighboring gene Peptidase M16 N-terminal domain-containing protein Neighboring gene Zyg eleven-related protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions. Irazoqui JE, et al. Proc Natl Acad Sci U S A, 2008 Nov 11. PMID 18981407, Free PMC Article
    2. p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. Troemel ER, et al. PLoS Genet, 2006 Nov 10. PMID 17096597, Free PMC Article
    3. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 225
    NP_497282.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      872621..873566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064881.8 → NP_497282.2  Transmembrane protein 225 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497282.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZ35
      Conserved Domains (1) summary
      pfam06653
      Location:78 → 155
      Claudin_3; Tight junction protein, Claudin-like
    Nucleotide Protein
    Heading Accession and Version

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