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    test-1 Thyroglobulin type-1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177010, updated on 9-Dec-2024

    Summary

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    Official Symbol
    test-1
    Official Full Name
    Thyroglobulin type-1 domain-containing protein
    Primary source
    WormBase:WBGene00016918
    Locus tag
    CELE_C54E4.2
    See related
    AllianceGenome:WB:WBGene00016918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1); SPOCK2 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2); and SPOCK3 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See test-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (2136951..2146467)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase domain-containing protein Neighboring gene Serpentine Receptor, class BC (Class B-like) Neighboring gene Secreted protein Neighboring gene Inositol oxygenase Neighboring gene Soluble guanylate cyclase gcy-37

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A basement membrane discovery pipeline uncovers network complexity, regulators, and human disease associations. Jayadev R, et al. Sci Adv, 2022 May 20. PMID 35584218, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thyroglobulin type-1 domain-containing protein
    NP_001023098.1
    • Confirmed by transcript evidence
    NP_001368220.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2136951..2146467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027927.6 → NP_001023098.1  Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023098.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44466
      Conserved Domains (2) summary
      cd00191
      Location:149 → 207
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd16232
      Location:40 → 142
      EFh_SPARC_TICN; EF-hand, extracellular calcium-binding (EC) motif, found in testicans

    2. NM_001380084.1 → NP_001368220.1  Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PLP4
      Conserved Domains (2) summary
      cd00191
      Location:66 → 124
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cl25349
      Location:1 → 59
      EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
    Nucleotide Protein
    Heading Accession and Version

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