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    D2021.4 Acyl-CoA thioesterase-like C-terminal domain-containing protein;HotDog ACOT-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183943, updated on 9-Dec-2024

    Summary

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    Official Symbol
    D2021.4
    Official Full Name
    Acyl-CoA thioesterase-like C-terminal domain-containing protein;HotDog ACOT-type domain-containing protein
    Primary source
    WormBase:WBGene00017048
    Locus tag
    CELE_D2021.4
    See related
    AllianceGenome:WB:WBGene00017048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid catabolic process. Predicted to be active in peroxisomal matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See D2021.4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    4
    Sequence:
    Chromosome: X; NC_003284.9 (8546448..8549056, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Palmitoyltransferase Neighboring gene JmjC domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA thioesterase-like C-terminal domain-containing protein;HotDog ACOT-type domain-containing protein
    NP_001041236.1
    • Confirmed by transcript evidence
    NP_001379613.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8546448..8549056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392811.1 → NP_001379613.1  HotDog ACOT-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYE8
      Conserved Domains (1) summary
      COG1946
      Location:8 → 108
      TesB; Acyl-CoA thioesterase [Lipid transport and metabolism]

    2. NM_001047771.5 → NP_001041236.1  Acyl-CoA thioesterase-like C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041236.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1W0S0
      Conserved Domains (3) summary
      cd03444
      Location:196 → 282
      Thioesterase_II_repeat1; Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) ...
      TIGR00189
      Location:15 → 283
      tesB; acyl-CoA thioesterase II
      cl00509
      Location:20 → 88
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
    Nucleotide Protein
    Heading Accession and Version

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