sos-1 Son of sevenless homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sos-1
Official Full Name: Son of sevenless homolog
Primary source: WormBase:WBGene00004947
Locus tag: CELE_T28F12.3
See related: AllianceGenome:WB:WBGene00004947
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; female gamete generation; and positive regulation of vulval development. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); atrial heart septal defect; gingival fibromatosis; and pulmonary valve stenosis. Orthologous to several human genes including SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sos-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 19

Sequence:: Chromosome: V; NC_003283.11 (4516944..4549291, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that the C. elegans mutation, as well as an equivalent mutation in human SOS1, activates the MAPK pathway by disrupting an autoinhibitory function of the Dbl domain on Ras activation.
Title: An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y61A9LA_70.a (e-PCR)
- UniSTS:323184

Y61A9LA_73.a (e-PCR)
- UniSTS:323191

T28F12.3 (e-PCR)
- UniSTS:321701

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Son of sevenless homolog

NP_001360576.1

Partially confirmed by transcript evidence

NP_504235.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4516944..4549291 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071834.5 → NP_504235.2 Son of sevenless homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504235.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N5D3, Q9NBD3

Conserved Domains (5) summary

pfam00169
Location:518 → 604

PH; PH domain

pfam00617
Location:900 → 1066

RasGEF; RasGEF domain

pfam00618
Location:659 → 794

RasGEF_N; RasGEF N-terminal motif

cl02571
Location:248 → 447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:493 → 604

PH-like; Pleckstrin homology-like domain
NM_001373020.3 → NP_001360576.1 Son of sevenless homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WXD9

Conserved Domains (5) summary

pfam00617
Location:900 → 1069

RasGEF; RasGEF domain

pfam00618
Location:659 → 794

RasGEF_N; RasGEF N-terminal motif

pfam06583
Location:1148 → 1377

Neogenin_C; Neogenin C-terminus

cl02571
Location:248 → 447

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl17171
Location:493 → 604

PH-like; Pleckstrin homology-like domain