U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ephx-1 SH2 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173742, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ephx-1
    Official Full Name
    SH2 domain-containing protein
    Primary source
    WormBase:WBGene00019487
    Locus tag
    CELE_K07D4.7
    See related
    AllianceGenome:WB:WBGene00019487
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of actin cytoskeleton organization. Is expressed in arcade cell; head; hypodermis; and reproductive system. Orthologous to several human genes including ARHGEF16 (Rho guanine nucleotide exchange factor 16) and ARHGEF26 (Rho guanine nucleotide exchange factor 26). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ephx-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (4004914..4016081)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene DUF998 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene S-protein homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A systems biology-based identification and in vivo functional screening of Alzheimer's disease risk genes reveal modulators of memory function. Hudgins AD, et al. Neuron, 2024 Jul 3. PMID 38692279,
    2. The Integrin Signaling Network Promotes Axon Regeneration via the Src-Ephexin-RhoA GTPase Signaling Axis. Sakai Y, et al. J Neurosci, 2021 Jun 2. PMID 33963050, Free PMC Article
    3. CDK14 Promotes Axon Regeneration by Regulating the Noncanonical Wnt Signaling Pathway in a Kinase-Independent Manner. Hisamoto N, et al. J Neurosci, 2021 Oct 6. PMID 34429379, Free PMC Article
    4. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SH2 domain-containing protein
    NP_001333554.1
    • Confirmed by transcript evidence
    NP_001364792.1
    • Confirmed by transcript evidence
    NP_001364847.1
    • Confirmed by transcript evidence
    NP_494706.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      4004914..4016081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062305.8 → NP_494706.2  SH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965J0

    2. NM_001377776.2 → NP_001364847.1  SH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PCN4
      Conserved Domains (3) summary
      cd11793
      Location:904 → 958
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:754 → 891
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:547 → 729
      RhoGEF; RhoGEF domain

    3. NM_001346626.3 → NP_001333554.1  SH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1D3PD25

    4. NM_001377777.2 → NP_001364792.1  SH2 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76572
      Conserved Domains (3) summary
      cd11793
      Location:533 → 587
      SH3_ephexin1_like; Src homology 3 domain of ephexin-1-like SH3 domain containing Rho guanine nucleotide exchange factors
      cd01221
      Location:383 → 520
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:176 → 358
      RhoGEF; RhoGEF domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.