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    aakg-4 CBS domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 187928, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aakg-4
    Official Full Name
    CBS domain-containing protein
    Primary source
    WormBase:WBGene00020135
    Locus tag
    CELE_T01B6.3
    See related
    AllianceGenome:WB:WBGene00020135
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Predicted to be involved in cellular response to glucose starvation; regulation of carbohydrate metabolic process; and regulation of carbon utilization. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including accessory cell; dorsal nerve cord; neurons; non-striated muscle; and rectal epithelium. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aakg-4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    11
    Sequence:
    Chromosome: X; NC_003284.9 (2314894..2319338, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sulfhydryl oxidase Neighboring gene ncRNA Neighboring gene Unconventional myosin heavy chain 6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans. Tullet JM, et al. PLoS Genet, 2014 Feb. PMID 24516399, Free PMC Article
    2. C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens. Ju S, et al. Commun Biol, 2022 Jun 30. PMID 35773333, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to glucose starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of carbon utilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-activated protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CBS domain-containing protein
    NP_741725.2
    • Confirmed by transcript evidence
    NP_741726.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2314894..2319338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171633.7 → NP_741726.2  CBS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741726.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MPT4
      Conserved Domains (1) summary
      cd02205
      Location:6 → 120
      CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

    2. NM_171632.4 → NP_741725.2  CBS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741725.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0K0
      Conserved Domains (3) summary
      COG0517
      Location:318 → 436
      CBS; CBS domain [Signal transduction mechanisms]
      cd02205
      Location:319 → 438
      CBS_pair; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
      cd04618
      Location:163 → 288
      CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
    Nucleotide Protein
    Heading Accession and Version

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