hrpf-2 RRM domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hrpf-2
Official Full Name: RRM domain-containing protein
Primary source: WormBase:WBGene00022253
Locus tag: CELE_Y73B6BL.33
See related: AllianceGenome:WB:WBGene00022253
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in Sjogren's syndrome and syndromic X-linked intellectual developmental disorder bain type. Orthologous to several human genes including GRSF1 (G-rich RNA sequence binding factor 1) and HNRNPF (heterogeneous nuclear ribonucleoprotein F). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hrpf-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (6373134..6376523, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RRM domain-containing protein

NP_001368405.1

Confirmed by transcript evidence

NP_741422.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6373134..6376523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171360.5 → NP_741422.1 RRM domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741422.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MXR2

Conserved Domains (3) summary

PRK07764
Location:400 → 590

PRK07764; DNA polymerase III subunits gamma and tau; Validated

cd12254
Location:158 → 232

RRM_hnRNPH_ESRPs_RBM12_like; RNA recognition motif found in heterogeneous nuclear ribonucleoprotein (hnRNP) H protein family, epithelial splicing regulatory proteins (ESRPs), Drosophila RNA-binding protein Fusilli, RNA-binding protein 12 (RBM12) and similar proteins

cl17169
Location:326 → 398

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001380274.1 → NP_001368405.1 RRM domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

V6CLR1

Conserved Domains (1) summary

cl17169
Location:64 → 136

RRM_SF; RNA recognition motif (RRM) superfamily