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    melo-1 RRM domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    melo-1
    Official Full Name
    RRM domain-containing protein
    Primary source
    WormBase:WBGene00013307
    Locus tag
    CELE_Y57G11C.9
    See related
    AllianceGenome:WB:WBGene00013307
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of gene expression, epigenetic and protein localization to heterochromatin. Predicted to be active in nucleoplasm. Orthologous to human PPHLN1 (periphilin 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See melo-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (14787031..14790843)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cyclin N-terminal domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-Like Protein Neighboring gene Rab GDP dissociation inhibitor Neighboring gene Ubiquinone biosynthesis O-methyltransferase, mitochondrial Neighboring gene Protein BRICK1 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness. Norris AD, et al. Elife, 2017 Jul 18. PMID 28718764, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein
    NP_001263816.1
    • Confirmed by transcript evidence
    NP_001379285.1
    • Partially confirmed by transcript evidence
    NP_502785.2
    • Confirmed by transcript evidence
    NP_502786.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14787031..14790843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392443.1 → NP_001379285.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q12

    2. NM_070384.6 → NP_502785.2  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502785.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U202
      Conserved Domains (1) summary
      cd00590
      Location:52 → 123
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_070385.7 → NP_502786.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U203
      Conserved Domains (1) summary
      cd00590
      Location:52 → 123
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001276887.3 → NP_001263816.1  RRM domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263816.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8FDY2
    Nucleotide Protein
    Heading Accession and Version

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