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    mig-23 Nucleoside-diphosphatase mig-23 [ Caenorhabditis elegans ]

    Gene ID: 180860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mig-23
    Official Full Name
    Nucleoside-diphosphatase mig-23
    Primary source
    WormBase:WBGene00003254
    Locus tag
    CELE_R07E4.4
    See related
    AllianceGenome:WB:WBGene00003254
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ADP phosphatase activity; GDP phosphatase activity; and UDP phosphatase activity. Involved in several processes, including gonad morphogenesis; positive regulation of protein glycosylation; and ribonucleoside diphosphate catabolic process. Located in cytoplasm. Is expressed in head; hypodermis; intestine; pharynx; and tail. Orthologous to human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mig-23 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (5945813..5948869, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene EB domain-containing protein Neighboring gene long-chain-fatty-acid--CoA ligase Neighboring gene VWFA domain-containing protein Neighboring gene Cytochrome b-c1 complex subunit 8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sweet control of cell migration, cytokinesis and organogenesis. Podbilewicz B. Nat Cell Biol, 2004 Jan. PMID 14704673
    2. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. Uccelletti D, et al. J Biol Chem, 2004 Jun 25. PMID 15102851
    3. An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans. Nishiwaki K, et al. Nat Cell Biol, 2004 Jan. PMID 14688791
    4. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Kubota Y, et al. Development, 2006 Jan. PMID 16354716
    5. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Zhang Z, et al. Sci Adv, 2020 Feb. PMID 32095531, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ADP phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ADP phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GDP phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables UDP phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ADP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in CTP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in GDP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UDP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in UDP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gonad morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonadal mesoderm development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleoside-diphosphatase mig-23
    NP_508994.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      5945813..5948869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076593.8 → NP_508994.1  Nucleoside-diphosphatase mig-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21815
      Conserved Domains (1) summary
      pfam01150
      Location:35 → 482
      GDA1_CD39; GDA1/CD39 (nucleoside phosphatase) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21815.2

    Gene LinkOut

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