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    ddx-15 Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 175771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx-15
    Official Full Name
    Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase
    Primary source
    WormBase:WBGene00018967
    Locus tag
    CELE_F56D2.6
    See related
    AllianceGenome:WB:WBGene00018967
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in rRNA processing. Predicted to be located in nucleus. Predicted to be part of spliceosomal complex. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddx-15 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5589036..5591718, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene UBC core domain-containing protein Neighboring gene DUF148 domain-containing protein Neighboring gene RBR-type E3 ubiquitin transferase Neighboring gene Cytochrome b-c1 complex subunit 1, mitochondrial;Peptidase M16 C-terminal domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegansddx-15 helicase fails to complement loss of Prp43p in Saccharomyces cerevisiae. Karpel JE. MicroPubl Biol, 2024. PMID 38344068, Free PMC Article
    2. RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation. Tariq A, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275536, Free PMC Article
    3. Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Arur S, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19264959, Free PMC Article
    4. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15;RNA helicase
    NP_741147.1
    • Confirmed by transcript evidence
    NP_741148.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5589036..5591718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171130.5 → NP_741147.1  Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741147.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20875
      Conserved Domains (6) summary
      smart00490
      Location:327 → 419
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:70 → 266
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:489 → 572
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:95 → 239
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cl22853
      Location:41 → 106
      Motor_domain; Myosin and Kinesin motor domain
      pfam07717
      Location:607 → 709
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. NM_171131.10 → NP_741148.2  RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741148.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY03
      Conserved Domains (6) summary
      smart00490
      Location:327 → 419
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:70 → 266
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:489 → 572
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:95 → 239
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cl22853
      Location:41 → 106
      Motor_domain; Myosin and Kinesin motor domain
      pfam07717
      Location:607 → 700
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20875.1

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