C5ar2 complement C5a receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C5ar2provided by RGD
Official Full Name: complement C5a receptor 2provided by RGD
Primary source: RGD:1303027
See related: EnsemblRapid:ENSRNOG00000049028 AllianceGenome:RGD:1303027
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C5L2; Gpr77
Summary: Predicted to enable G protein-coupled receptor activity and complement component C5a receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; negative regulation of neutrophil chemotaxis; and regulation of cytokine production. Predicted to be located in apical part of cell and basal plasma membrane. Predicted to be active in plasma membrane. Orthologous to human C5AR2 (complement C5a receptor 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Spleen (RPKM 46.8), Lung (RPKM 43.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (86058557..86073583, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (76930381..76945432, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (78165155..78183426, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C5aR and C5L2, but not C3aR, are expressed on CD11b-positive leukocytes in islet preparations
Title: Expression of receptors for anaphylatoxins C3a and C5a on rat islet preparations.
C5a receptors and C5L2 were demonstrated in the rat anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH.
Title: Complement C5a receptors in the pituitary gland: expression and function.
C5L2 is a highly regulated scavenger receptor for C5a and C5a-des-Arg(74)
Title: Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.
data provide the first evidence for a role for C5a receptor C5L2 in balancing the biological responses to Complement 5a
Title: Evidence for a functional role of the second C5a receptor C5L2.
Following cecal ligation and puncture-induced sepsis in rats, neutrophils demonstrated a time-dependent decrease in C5L2.
Title: Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.
C5L2 appears to bind complement factor C5a and its C-terminal cleavage product C5a des Arg by different mechanisms, and, unlike C5a receptor (C5aR), C5L2 uses critical residues in its N-terminal domain for binding only to C5a des Arg.
Title: The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.
A C5aR isoform expressed by glia and neurons is regulated by NA and exerts anti-inflammatory functions. Changes in C5aR isoform levels in diseased brain could therefore contribute to the progression of inflammatory damage.
Title: Identification of complement 5a-like receptor (C5L2) from astrocytes: characterization of anti-inflammatory properties.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement component C5a signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement receptor mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C5a anaphylatoxin chemotactic receptor 2

Names: C5A receptor beta; C5a anaphylatoxin chemotactic receptor C5L2; G protein-coupled receptor 77; complement 5A receptor beta; complement component 5a receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003710.3 → NP_001003710.3 C5a anaphylatoxin chemotactic receptor 2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q695P6

UniProtKB/TrEMBL

A6J8A1, Q5XPY4

Conserved Domains (2) summary

cd14964
Location:43 → 69

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:42 → 309

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

86058557..86073583 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006228352.5 → XP_006228414.1 C5a anaphylatoxin chemotactic receptor 2 isoform X1

UniProtKB/TrEMBL

A0A8L2QZB1, Q5XPY4

Conserved Domains (1) summary

pfam00001
Location:101 → 338

7tm_1; 7 transmembrane receptor (rhodopsin family)
XM_006228353.5 → XP_006228415.1 C5a anaphylatoxin chemotactic receptor 2 isoform X2

See identical proteins and their annotated locations for XP_006228415.1

UniProtKB/Swiss-Prot

Q695P6

UniProtKB/TrEMBL

A6J8A1, Q5XPY4

Related

ENSRNOP00000081314.1, ENSRNOT00000102131.2

Conserved Domains (2) summary

cd14964
Location:43 → 69

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:42 → 309

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily