Filip1 filamin A interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Filip1provided by RGD
Official Full Name: filamin A interacting protein 1provided by RGD
Primary source: RGD:628597
See related: EnsemblRapid:ENSRNOG00000011521 AllianceGenome:RGD:628597
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Filip
Summary: Predicted to be involved in modification of postsynaptic structure and protein localization to actin cytoskeleton. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human FILIP1 (filamin A interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 190.5), Heart (RPKM 189.5) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (89641509..89836772, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (80761283..80956556, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (87257312..87453432, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that the amount of Filamin A helps migrating neurons determine their mode of migration, multipolar or bipolar, before entering the cortical plate and that FILIP is responsible, at least in part, for Filamin A content.
Title: Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration.
FILIP interacts with Filamin A, an indispensable actin-binding protein that is required for cell motility (filamin A)
Title: Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in modification of postsynaptic structure	IEA Inferred from Electronic Annotation more info
involved_in modification of postsynaptic structure	ISO Inferred from Sequence Orthology more info
involved_in protein localization to actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: filamin-A-interacting protein 1

Names: filamin-interacting protein L-Filip; filamin-interacting protein S-Filip

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145682.2 → NP_663715.2 filamin-A-interacting protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q8JZS5, Q8K4T4

UniProtKB/TrEMBL

A6I1M6

Related

ENSRNOP00000015365.8, ENSRNOT00000015365.10

Conserved Domains (3) summary

PRK03918
Location:204 → 745

PRK03918; DNA double-strand break repair ATPase Rad50

pfam05109
Location:913 → 1177

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09727
Location:73 → 255

CortBP2; Cortactin-binding protein-2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

89641509..89836772 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595471.3 → XP_017450960.3 filamin-A-interacting protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I5YBS3
XM_017595472.3 → XP_017450961.3 filamin-A-interacting protein 1 isoform X5

UniProtKB/TrEMBL

A0A0G2K6B7
XM_017595467.3 → XP_017450956.1 filamin-A-interacting protein 1 isoform X2

UniProtKB/Swiss-Prot

Q8JZS5, Q8K4T4
XM_017595468.3 → XP_017450957.1 filamin-A-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

Q8JZS5, Q8K4T4

UniProtKB/TrEMBL

A6I1M6

Conserved Domains (3) summary

PRK03918
Location:204 → 745

PRK03918; DNA double-strand break repair ATPase Rad50

pfam05109
Location:913 → 1177

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09727
Location:73 → 255

CortBP2; Cortactin-binding protein-2
XM_017595469.3 → XP_017450958.1 filamin-A-interacting protein 1 isoform X3

UniProtKB/Swiss-Prot

Q8JZS5, Q8K4T4

UniProtKB/TrEMBL

A6I1M6

Conserved Domains (3) summary

PRK03918
Location:204 → 745

PRK03918; DNA double-strand break repair ATPase Rad50

pfam05109
Location:913 → 1177

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09727
Location:73 → 255

CortBP2; Cortactin-binding protein-2
XM_063264922.1 → XP_063120992.1 filamin-A-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q8JZS5, Q8K4T4
XM_017595474.3 → XP_017450963.1 filamin-A-interacting protein 1 isoform X6

UniProtKB/TrEMBL

F1LM79

Related

ENSRNOP00000070886.3, ENSRNOT00000087874.3