Dlec1 DLEC1 cilia and flagella associated protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlec1provided by RGD
Official Full Name: DLEC1 cilia and flagella associated proteinprovided by RGD
Primary source: RGD:1561649
See related: EnsemblRapid:ENSRNOG00000032085 AllianceGenome:RGD:1561649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable alpha-tubulin binding activity and beta-tubulin binding activity. Predicted to be involved in defense response to tumor cell and spermatogenesis. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 23.9), Lung (RPKM 12.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (127704181..127750929)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (118826429..118873183)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (127788919..127835986)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	IEA Inferred from Electronic Annotation more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	IEA Inferred from Electronic Annotation more info
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deleted in lung and esophageal cancer protein 1 homolog

Names: deleted in lung and esophageal cancer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419664.1 → NP_001406593.1 deleted in lung and esophageal cancer protein 1 homolog

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I3V1, D3ZAF3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

127704181..127750929

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082713.2 → XP_038938641.1 deleted in lung and esophageal cancer protein 1 homolog isoform X9

Conserved Domains (1) summary

cl13764
Location:608 → 713

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_063266030.1 → XP_063122100.1 deleted in lung and esophageal cancer protein 1 homolog isoform X5

UniProtKB/TrEMBL

A6I3V1

Related

ENSRNOP00000107740.1, ENSRNOT00000160915.1
XM_039082704.2 → XP_038938632.1 deleted in lung and esophageal cancer protein 1 homolog isoform X1

UniProtKB/TrEMBL

A6I3V1

Related

ENSRNOP00000043711.5, ENSRNOT00000052275.5

Conserved Domains (1) summary

cl13764
Location:608 → 713

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_039082705.2 → XP_038938633.1 deleted in lung and esophageal cancer protein 1 homolog isoform X2

UniProtKB/TrEMBL

A6I3V1

Conserved Domains (1) summary

cl13764
Location:607 → 712

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_039082706.2 → XP_038938634.1 deleted in lung and esophageal cancer protein 1 homolog isoform X3

UniProtKB/TrEMBL

A6I3V1

Conserved Domains (1) summary

cl13764
Location:603 → 708

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_039082707.2 → XP_038938635.1 deleted in lung and esophageal cancer protein 1 homolog isoform X4

UniProtKB/TrEMBL

A6I3V1

Conserved Domains (1) summary

cl13764
Location:608 → 713

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_063266031.1 → XP_063122101.1 deleted in lung and esophageal cancer protein 1 homolog isoform X6

UniProtKB/TrEMBL

A6I3V1
XM_039082711.1 → XP_038938639.1 deleted in lung and esophageal cancer protein 1 homolog isoform X7

Conserved Domains (1) summary

cl13764
Location:132 → 237

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_039082712.1 → XP_038938640.1 deleted in lung and esophageal cancer protein 1 homolog isoform X8

Conserved Domains (1) summary

cl13764
Location:73 → 178

ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
XM_039082714.2 → XP_038938642.1 deleted in lung and esophageal cancer protein 1 homolog isoform X10

RNA

XR_005488550.2 RNA Sequence

Related

ENSRNOT00000109598.2
XR_010054018.1 RNA Sequence
XR_010054019.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001025154.1: Suppressed sequence

Description

NM_001025154.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.