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    Ptpn9 protein tyrosine phosphatase, non-receptor type 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266611, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptpn9provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 9provided by RGD
    Primary source
    RGD:628726
    See related
    EnsemblRapid:ENSRNOG00000017600 AllianceGenome:RGD:628726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Meg2
    Summary
    Enables protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and positive regulation of protein localization to plasma membrane. Predicted to be located in cytoplasm and neuron projection terminus. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 146.5), Lung (RPKM 94.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn9 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66286771..66368306)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57391290..57472352)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61658851..61739458)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3 Neighboring gene snurportin 1 Neighboring gene uncharacterized LOC103693102 Neighboring gene uncharacterized LOC102553607 Neighboring gene uncharacterized LOC120094171 Neighboring gene SIN3 transcription regulator family member A Neighboring gene uncharacterized LOC120094172

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enlargement of secretory vesicles by protein tyrosine phosphatase PTP-MEG2 in rat basophilic leukemia mast cells and Jurkat T cells. Wang X, et al. J Immunol, 2002 May 1. PMID 11971009
    2. The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A. Zhang D, et al. J Biol Chem, 2016 Nov 11. PMID 27655914, Free PMC Article
    3. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933
    4. Large-scale structural analysis of the classical human protein tyrosine phosphatome. Barr AJ, et al. Cell, 2009 Jan 23. PMID 19167335, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. As a result, overexpression of PTP-MEG2 down-regulates NGF/TrkA signaling and blocks neurite outgrowth and differentiation
      Title: The Protein Tyrosine Phosphatase MEG2 Regulates the Transport and Signal Transduction of Tropomyosin Receptor Kinase A.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 9
    NP_001013058.1
    XP_006243168.1
    XP_038936852.1
    XP_063121057.1
    XP_063121058.1
    XP_063121059.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013040.1 → NP_001013058.1  tyrosine-protein phosphatase non-receptor type 9

      See identical proteins and their annotated locations for NP_001013058.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082041
      UniProtKB/Swiss-Prot
      Q641Z2, Q8K3Y9
      UniProtKB/TrEMBL
      A0A0G2K6A2, A6J4S3
      Related
      ENSRNOP00000084715.2, ENSRNOT00000114994.2
      Conserved Domains (4) summary
      smart00194
      Location:302 → 573
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00516
      Location:90 → 238
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:20 → 66
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00047
      Location:329 → 573
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66286771..66368306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243106.5 → XP_006243168.1  tyrosine-protein phosphatase non-receptor type 9 isoform X3

      Conserved Domains (4) summary
      smart00194
      Location:302 → 458
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00516
      Location:90 → 238
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:20 → 66
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd00047
      Location:329 → 466
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_063264987.1 → XP_063121057.1  tyrosine-protein phosphatase non-receptor type 9 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1V8
      Related
      ENSRNOP00000104151.1, ENSRNOT00000159051.1

    3. XM_039080924.2 → XP_038936852.1  tyrosine-protein phosphatase non-receptor type 9 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6A2
      Related
      ENSRNOP00000023831.6, ENSRNOT00000023831.8
      Conserved Domains (3) summary
      smart00516
      Location:73 → 221
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:4 → 49
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      cd14543
      Location:282 → 552
      PTPc-N9; catalytic domain of tyrosine-protein phosphatase non-receptor type 9

    4. XM_063264989.1 → XP_063121059.1  tyrosine-protein phosphatase non-receptor type 9 isoform X5

    5. XM_063264988.1 → XP_063121058.1  tyrosine-protein phosphatase non-receptor type 9 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641Z2.1 GenPept UniProtKB/Swiss-Prot:Q641Z2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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