U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pfdn5 prefoldin subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300257, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pfdn5provided by RGD
    Official Full Name
    prefoldin subunit 5provided by RGD
    Primary source
    RGD:1311436
    See related
    EnsemblRapid:ENSRNOG00000012985 AllianceGenome:RGD:1311436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of macromolecule metabolic process; and protein-containing complex assembly. Predicted to act upstream of or within retina development in camera-type eye. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 751.5), Kidney (RPKM 729.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pfdn5 in Genome Data Viewer
    Location:
    7q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135330364..135335102)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133451778..133456516)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143924662..143929400)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene extra spindle pole bodies like 1, separase Neighboring gene uncharacterized LOC134479583 Neighboring gene MYG1 exonuclease Neighboring gene aladin WD repeat nucleoporin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA polymerase I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA polymerase II core complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA polymerase III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prefoldin subunit 5
    Names
    prefoldin 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106794.2NP_001100264.2  prefoldin subunit 5

      See identical proteins and their annotated locations for NP_001100264.2

      Status: VALIDATED

      Source sequence(s)
      AI576681, CF976389, CF976393
      UniProtKB/TrEMBL
      B5DFN4, F7FF81
      Related
      ENSRNOP00000017794.7, ENSRNOT00000017794.7
      Conserved Domains (1) summary
      TIGR00293
      Location:12138
      TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      135330364..135335102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)