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    B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64828, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B4galnt1provided by RGD
    Official Full Name
    beta-1,4-N-acetyl-galactosaminyl transferase 1provided by RGD
    Primary source
    RGD:620490
    See related
    EnsemblRapid:ENSRNOG00000004839 AllianceGenome:RGD:620490
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Galgt1; GalNAc-T
    Summary
    Enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity. Involved in ganglioside biosynthetic process. Located in Golgi membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 26. Orthologous to human B4GALNT1 (beta-1,4-N-acetyl-galactosaminyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 108.1), Spleen (RPKM 72.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B4galnt1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64873909..64881512)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62988429..62996190)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70439273..70459556)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene coenzyme Q4, pseudogene 1 Neighboring gene ribosomal protein S26 like 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene uncharacterized LOC134479708 Neighboring gene deltex E3 ubiquitin ligase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. beta 1-4N-acetylgalactosaminyltransferase can synthesize both asialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and in vivo: isolation and characterization of a beta 1-4N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatoma cell line AH7974F. Hidari JK, et al. Biochem J, 1994 Nov 1. PMID 7980468, Free PMC Article
    2. Both GA2, GM2, and GD2 synthases and GM1b, GD1a, and GT1b synthases are single enzymes in Golgi vesicles from rat liver. Pohlentz G, et al. Proc Natl Acad Sci U S A, 1988 Oct. PMID 3140234, Free PMC Article
    3. Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system. Takamiya K, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855236, Free PMC Article
    4. Substrate specificity of beta 1,4-N-acetylgalactosaminyltransferase in vitro and in cDNA-transfected cells. GM2/GD2 synthase efficiently generates asialo-GM2 in certain cells. Yamashiro S, et al. J Biol Chem, 1995 Mar 17. PMID 7890749
    5. Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression. Ruan S, et al. Arch Biochem Biophys, 1995 Oct 20. PMID 7487055

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93424

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate derivative biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ganglioside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ganglioside biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ganglioside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ganglioside biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycosphingolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycosphingolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glycosphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in limb development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within limb development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within motor behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nerve development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nerve development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vacuole organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vacuole organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4 N-acetylgalactosaminyltransferase 1
    Names
    (N-acetylneuraminyl)-galactosylglucosylceramide
    GA2 synthase
    GD2 synthase
    GM2 synthase
    GM2/GD2 synthase
    UDP-N-acetyl-alpha-D-galactosamine:(N-acetylneuraminyl)-galactosylglucosylceramide-beta-1, 4-N-acetylgalactosaminyltransferase
    beta-4N-acetylgalactosaminyltransferase
    NP_074051.1
    XP_006241559.1
    XP_038935786.2
    XP_063120284.1
    XP_063120285.1
    XP_063120286.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022860.2 → NP_074051.1  beta-1,4 N-acetylgalactosaminyltransferase 1

      See identical proteins and their annotated locations for NP_074051.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081799
      UniProtKB/Swiss-Prot
      Q10468
      UniProtKB/TrEMBL
      A0A8L2QP76, A6HQS8
      Conserved Domains (1) summary
      pfam00535
      Location:280 → 426
      Glycos_transf_2; Glycosyl transferase family 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64873909..64881512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264214.1 → XP_063120284.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QP76, A6HQS6

    2. XM_039079858.2 → XP_038935786.2  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q10468
      UniProtKB/TrEMBL
      A0A8L2QP76, A6HQS8

    3. XM_063264215.1 → XP_063120285.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLQ7, A0A8L2QP76
      Related
      ENSRNOP00000078917.1, ENSRNOT00000097144.2

    4. XM_006241497.5 → XP_006241559.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLQ7, A0A8L2QP76
      Conserved Domains (2) summary
      COG0463
      Location:299 → 397
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      pfam00535
      Location:301 → 447
      Glycos_transf_2; Glycosyl transferase family 2

    5. XM_063264216.1 → XP_063120286.1  beta-1,4 N-acetylgalactosaminyltransferase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q10468
      UniProtKB/TrEMBL
      A0A8L2QP76, A6HQS8
      Related
      ENSRNOP00000088949.2, ENSRNOT00000104089.2

    RNA

    1. XR_001838716.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10468.1 GenPept UniProtKB/Swiss-Prot:Q10468

    Gene LinkOut

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