Psma6 proteasome 20S subunit alpha 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Psma6provided by RGD
Official Full Name: proteasome 20S subunit alpha 6provided by RGD
Primary source: RGD:61849
See related: EnsemblRapid:ENSRNOG00000007114 AllianceGenome:RGD:61849
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NF-kappaB binding activity and RNA binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in sarcomere. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 1339.4), Muscle (RPKM 864.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (78500676..78531693)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (72765534..72796554)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (76174460..76205429)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSMA6 mRNA is post-transcriptionally regulated by miRNA-4490, whose expression is inversely correlated to PSMA6 protein expression.
Title: Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, alpha-subunit complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info
located_in ribosome	ISO Inferred from Sequence Orthology more info
located_in ribosome	ISS Inferred from Sequence or Structural Similarity more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome subunit alpha type-6

Names: alpha-1; macropain iota chain; multicatalytic endopeptidase complex iota chain; proteasome (prosome, macropain) subunit, alpha type 6; proteasome alpha 6 subunit; proteasome iota chain; proteasome subunit alpha 6; proteasome subunit alpha-1

NP_058979.1

EC 3.4.25.1

XP_006240160.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017283.3 → NP_058979.1 proteasome subunit alpha type-6

See identical proteins and their annotated locations for NP_058979.1

Status: PROVISIONAL

Source sequence(s)

BC062232

UniProtKB/Swiss-Prot

P60901

UniProtKB/TrEMBL

A0A8I6GE69, A6HBM1

Related

ENSRNOP00000009666.4, ENSRNOT00000009666.8

Conserved Domains (1) summary

cd03754
Location:8 → 220

proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

78500676..78531693

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240098.5 → XP_006240160.1 proteasome subunit alpha type-6 isoform X1

UniProtKB/TrEMBL

A0A0G2K0D7, A0A8I6GE69

Related

ENSRNOP00000071403.2, ENSRNOT00000084062.3

Conserved Domains (1) summary

cd03754
Location:8 → 201

proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...