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    Ggh gamma-glutamyl hydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25455, updated on 9-Dec-2024

    Summary

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    Symbol
    Gghprovided by RGD
    Full Name
    gamma-glutamyl hydrolaseprovided by RGD
    Primary source
    RGD:2682
    See related
    EnsemblRapid:ENSRNOG00000007351 AllianceGenome:RGD:2682
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables gamma-glutamyl-peptidase activity. Involved in several processes, including response to ethanol; response to insulin; and response to zinc ion. Located in extracellular space. Orthologous to human GGH (gamma-glutamyl hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 360.7), Spleen (RPKM 264.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggh in Genome Data Viewer
    Location:
    5q13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (38326747..38349655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (33529880..33552790)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (34040258..34063369)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478943 Neighboring gene U4 spliceosomal RNA Neighboring gene alpha tocopherol transfer protein Neighboring gene Sodium/potassium transporting ATPase interacting 3 Neighboring gene histone deacetylase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p. Wein SA, et al. J Nutr Biochem, 2015 Dec. PMID 26432773
    2. The effect of dietary zinc depletion and repletion on rats: Zn concentration in various tissues and activity of pancreatic gamma-glutamyl hydrolase (EC 3.4.22.12) as indices of Zn status. Canton MC, et al. Br J Nutr, 1990 Jul. PMID 2400760
    3. Subcellular fractionation of liver organelles from phenobarbital-treated rats by counter-current partition and sucrose gradient centrifugation. Morris WB, et al. Biochem Pharmacol, 1986 Jul 1. PMID 3015147
    4. Effect of chronic ethanol consumption on the cellular and subcellular distribution of gamma-glutamyltransferase in rat liver. Halsall S, et al. Enzyme, 1984. PMID 6147245
    5. Insulin-dependent suppression in glutamyl hydrolase activity and elevated cellular methotrexate polyglutamates. Galivan J, et al. Biochem Pharmacol, 1995 Nov 9. PMID 7503769

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hepatic microRNA rno-miR-125b-3p is suppressed by quercetin-induced hepatic gamma-glutamyl hydrolase expression in rats
      Title: Quercetin induces hepatic γ-glutamyl hydrolase expression in rats by suppressing hepatic microRNA rno-miR-125b-3p.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC105496

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-glutamyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-glutamyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-glutamyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-glutamyl-peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to insulin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to zinc ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tetrahydrofolylpolyglutamate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamyl hydrolase
    Names
    GH
    conjugase
    gamma-Glu-X carboxypeptidase
    gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
    NP_037092.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012960.2 → NP_037092.1  gamma-glutamyl hydrolase precursor

      See identical proteins and their annotated locations for NP_037092.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087602
      UniProtKB/Swiss-Prot
      Q62867
      UniProtKB/TrEMBL
      A6IID6
      Related
      ENSRNOP00000009758.3, ENSRNOT00000009758.7
      Conserved Domains (2) summary
      pfam07722
      Location:34 → 245
      Peptidase_C26; Peptidase C26
      cl00020
      Location:36 → 305
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      38326747..38349655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62867.1 GenPept UniProtKB/Swiss-Prot:Q62867

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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