Elmod3 ELMO domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elmod3provided by RGD
Official Full Name: ELMO domain containing 3provided by RGD
Primary source: RGD:1306408
See related: EnsemblRapid:ENSRNOG00000038102 AllianceGenome:RGD:1306408
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kcmf1; Rbed1
Summary: Predicted to act upstream of or within several processes, including cilium assembly; inner ear receptor cell development; and sensory perception of sound. Predicted to be located in cytoskeleton; kinocilium; and stereocilium. Predicted to be active in Golgi apparatus and cilium. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness and autosomal recessive nonsyndromic deafness 88. Orthologous to human ELMOD3 (ELMO domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 181.1), Adrenal (RPKM 52.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106172819..106211286, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104614665..104653122, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100422256..100465152, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AU028826 (e-PCR)
- UniSTS:111949

RH133457 (e-PCR)
- UniSTS:216740

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
NOT enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within auditory receptor cell development	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in stereocilium maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stereocilium maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinocilium	IEA Inferred from Electronic Annotation more info
located_in stereocilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ELMO domain-containing protein 3

Names: ELMO/CED-12 domain containing 3; RNA binding motif and ELMO domain 1; RNA-binding motif and ELMO domain-containing protein 1; potassium channel modulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013087.1 → NP_001013105.1 ELMO domain-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_001013105.1

Status: PROVISIONAL

Source sequence(s)

BC083623

UniProtKB/Swiss-Prot

Q5XIQ2

UniProtKB/TrEMBL

A0A8I6AFQ0

Related

ENSRNOP00000054799.3, ENSRNOT00000057989.5

Conserved Domains (1) summary

pfam04727
Location:159 → 308

ELMO_CED12; ELMO/CED-12 family
NM_001398834.1 → NP_001385763.1 ELMO domain-containing protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2KBB8, A0A8I6AFQ0

Related

ENSRNOP00000075730.1, ENSRNOT00000086725.3

Conserved Domains (1) summary

pfam04727
Location:155 → 313

ELMO_CED12; ELMO/CED-12 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

106172819..106211286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762978.4 → XP_008761200.1 ELMO domain-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_008761200.1

UniProtKB/TrEMBL

A0A0G2KBB8, A0A8I6AFQ0

Conserved Domains (1) summary

pfam04727
Location:155 → 313

ELMO_CED12; ELMO/CED-12 family
XM_063285782.1 → XP_063141852.1 ELMO domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2KBB8, A0A8I6AFQ0
XM_017592542.3 → XP_017448031.1 ELMO domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2KBB8, A0A8I6AFQ0

Conserved Domains (1) summary

pfam04727
Location:155 → 313

ELMO_CED12; ELMO/CED-12 family
XM_063285781.1 → XP_063141851.1 ELMO domain-containing protein 3 isoform X1

UniProtKB/TrEMBL

A0A0G2KBB8, A0A8I6AFQ0
XM_063285785.1 → XP_063141855.1 ELMO domain-containing protein 3 isoform X3
XM_063285783.1 → XP_063141853.1 ELMO domain-containing protein 3 isoform X2

UniProtKB/Swiss-Prot

Q5XIQ2

UniProtKB/TrEMBL

A0A8I6AFQ0
XM_063285784.1 → XP_063141854.1 ELMO domain-containing protein 3 isoform X2

UniProtKB/Swiss-Prot

Q5XIQ2

UniProtKB/TrEMBL

A0A8I6AFQ0