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    Dmtf1 cyclin D binding myb-like transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dmtf1provided by RGD
    Official Full Name
    cyclin D binding myb-like transcription factor 1provided by RGD
    Primary source
    RGD:70966
    See related
    EnsemblRapid:ENSRNOG00000005908 AllianceGenome:RGD:70966
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human DMTF1 (cyclin D binding myb like transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 286.9), Spleen (RPKM 230.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dmtf1 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (25864891..25905916)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (24909937..24950786)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (21862297..21902798)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene endosome-lysosome associated apoptosis and autophagy regulator family member 2 Neighboring gene uncharacterized LOC108350658 Neighboring gene uncharacterized LOC102555663 Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 243 Neighboring gene uncharacterized LOC120102219 Neighboring gene uncharacterized LOC134486720

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and chromosomal localization of the gene encoding human cyclin D-binding Myb-like protein (hDMP1). Bodner SM, et al. Gene, 1999 Mar 18. PMID 10095122
    2. The Arf-inducing transcription factor Dmp1 encodes a transcriptional activator of amphiregulin, thrombospondin-1, JunB and Egr1. Mallakin A, et al. Int J Cancer, 2010 Mar 15. PMID 19816943, Free PMC Article
    3. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, et al. Cancer Res, 2001 Nov 15. PMID 11719459
    4. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, et al. Mamm Genome, 2001 Dec. PMID 11707776
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-D-binding Myb-like transcription factor 1
    Names
    cyclin D binding myb-like transcription factor 1D-interacting myb-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053693.1 → NP_446145.1  cyclin-D-binding Myb-like transcription factor 1

      See identical proteins and their annotated locations for NP_446145.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081880
      UniProtKB/TrEMBL
      A0A8L2UI49, A6K228
      Related
      ENSRNOP00000007948.6, ENSRNOT00000007948.8
      Conserved Domains (4) summary
      smart00717
      Location:274 → 330
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:338 → 388
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      25864891..25905916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592381.3 → XP_017447870.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q66HG1, Q99MC8
      UniProtKB/TrEMBL
      A0A8L2UI49
      Related
      ENSRNOP00000046030.3, ENSRNOT00000044810.8

    2. XM_063285395.1 → XP_063141465.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

    3. XM_039106913.1 → XP_038962841.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

      Conserved Domains (3) summary
      COG5147
      Location:122 → 378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam13921
      Location:228 → 284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam00249
      Location:274 → 329
      Myb_DNA-binding; Myb-like DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66HG1.2 GenPept UniProtKB/Swiss-Prot:Q66HG1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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