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    Arl5a ARF like GTPase 5A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arl5aprovided by RGD
    Official Full Name
    ARF like GTPase 5Aprovided by RGD
    Primary source
    RGD:621327
    See related
    EnsemblRapid:ENSRNOG00000006839 AllianceGenome:RGD:621327
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arl5
    Summary
    Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport; protein localization to Golgi membrane; and vesicle-mediated transport. Predicted to be active in trans-Golgi network. Orthologous to human ARL5A (ADP ribosylation factor like GTPase 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 255.9), Heart (RPKM 254.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arl5a in Genome Data Viewer
    Location:
    3q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (57287599..57312488, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (36878461..36903362, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (37922544..37947434, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 6, pseudogene 6 Neighboring gene cyclin-dependent kinase 4, pseudogene 3 Neighboring gene calcium voltage-gated channel auxiliary subunit beta 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene signal transducing adaptor molecule 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of a novel member (ARL5) of the ARF-family of Ras-related GTPases. Breiner M, et al. Biochim Biophys Acta, 1996 Jul 31. PMID 8765741
    2. The small G protein Arl5 contributes to endosome-to-Golgi traffic by aiding the recruitment of the GARP complex to the Golgi. Rosa-Ferreira C, et al. Biol Open, 2015 Mar 20. PMID 25795912, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 5A
    Names
    ADP-ribosylation factor like GTPase 5A
    ADP-ribosylation factor-like 5
    ADP-ribosylation factor-like 5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053979.2 → NP_446431.1  ADP-ribosylation factor-like protein 5A

      See identical proteins and their annotated locations for NP_446431.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097294
      UniProtKB/Swiss-Prot
      P51646, Q4V8N2
      UniProtKB/TrEMBL
      A6JF24
      Related
      ENSRNOP00000009181.1, ENSRNOT00000009181.4
      Conserved Domains (1) summary
      cd04153
      Location:3 → 175
      Arl5_Arl8; Arf-like 5 (Arl5) and 8 (Arl8) GTPases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      57287599..57312488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761696.4 → XP_008759918.1  ADP-ribosylation factor-like protein 5A isoform X1

      See identical proteins and their annotated locations for XP_008759918.1

      UniProtKB/TrEMBL
      A6JF25
      Conserved Domains (1) summary
      cl38936
      Location:1 → 138
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51646.1 GenPept UniProtKB/Swiss-Prot:P51646

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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