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    Ns5atp4-ps3 NS5A transactivated protein 4, pseudogene 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ns5atp4-ps3provided by RGD
    Official Full Name
    NS5A transactivated protein 4, pseudogene 3provided by RGD
    Primary source
    RGD:1303202
    See related
    EnsemblRapid:ENSRNOG00000027533 AllianceGenome:RGD:1303202
    Gene type
    pseudo
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ns5atp4l1-ps3
    Summary
    Predicted to be located in Golgi apparatus; membrane; and mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Ns5atp4-ps3 in Genome Data Viewer
    Location:
    3q12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (54874892..54875679, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (34465715..34466470, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (35542152..35542907, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 5C Neighboring gene uncharacterized LOC102556679 Neighboring gene Ly6/Plaur domain containing 6B Neighboring gene Ly6/Plaur domain containing 6 Neighboring gene transfer RNA valine (anticodon AAC) 2 Neighboring gene fatty acid-binding protein 5-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation. Choi JW, et al. Mol Cells, 2020 May 31. PMID 32344996, Free PMC Article
    2. Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles. Masaki T, et al. J Virol, 2008 Aug. PMID 18524832, Free PMC Article
    3. Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment. Li H, et al. J Virol, 2014 Jun. PMID 24623438, Free PMC Article
    4. Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes. Dal Pero F, et al. J Hepatol, 2007 Dec. PMID 17923166
    5. The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A. Helbig KJ, et al. Hepatology, 2011 Nov. PMID 22045669, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation.
      Title: Nonstructural NS5A Protein Regulates LIM and SH3 Domain Protein 1 to Promote Hepatitis C Virus Propagation.
    2. Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.
      Title: Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironment.
    3. We propose that viperin interacts with NS5A and the host factor, VAP-A, to limit hepatitis C virus replication at the replication complex.
      Title: The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
    4. NS5A plays a key role in regulating the early phase of HCV particle formation by interacting with core protein and its C-terminal serine cluster is a determinant of the NS5A-core interaction
      Title: Interaction of hepatitis C virus nonstructural protein 5A with core protein is critical for the production of infectious virus particles.
    5. The number of predicted CK2 sites correlated with the degree of in vitro and in vivo phosphorylation of NS5A by CK2. CK2-dependent phosphorylation of NS5A is heterogeneous among different HCV genotypes and clinical isolates.
      Title: Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Other Names

    • NS5A (hepatitis C virus) transactivated protein 4 like 1
    • NS5A transactivated protein 4 like 1, pseudogene 3

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      54874892..54875679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207607.1: Suppressed sequence

      Description
      NM_207607.1: This RefSeq was removed because it is now thought that this gene is a pseudogene.
    Nucleotide Protein Strain
    Heading Accession and Version

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