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    Srpk1 SRSF protein kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srpk1provided by RGD
    Official Full Name
    SRSF protein kinase 1provided by RGD
    Primary source
    RGD:1308272
    See related
    EnsemblRapid:ENSRNOG00000000511 AllianceGenome:RGD:1308272
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including regulation of mRNA processing; regulation of viral genome replication; and spliceosomal complex assembly. Predicted to be located in several cellular components, including chromatin; cytosol; and nuclear speck. Predicted to be active in cytoplasm and nucleus. Orthologous to human SRPK1 (SRSF protein kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 179.0), Thymus (RPKM 144.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srpk1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6647539..6684129, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6645809..6682448, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5829412..5865877, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene colipase Neighboring gene LHFPL tetraspan subfamily member 5 Neighboring gene uncharacterized LOC120098971 Neighboring gene solute carrier family 26 member 8 Neighboring gene mitogen activated protein kinase 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis. Li Z, et al. Mol Med, 2020 Nov 10. PMID 33167866, Free PMC Article
    2. SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms. Li XG, et al. CNS Neurosci Ther, 2019 Feb. PMID 30101479, Free PMC Article
    3. Inhibition of hepatitis C virus replication by a specific inhibitor of serine-arginine-rich protein kinase. Karakama Y, et al. Antimicrob Agents Chemother, 2010 Aug. PMID 20498328, Free PMC Article
    4. Cloning and characterization of an alternatively spliced form of SR protein kinase 1 that interacts specifically with scaffold attachment factor-B. Nikolakaki E, et al. J Biol Chem, 2001 Oct 26. PMID 11509566
    5. Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway. Kamachi M, et al. J Exp Med, 2002 Nov 4. PMID 12417631, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis.
      Title: Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis.
    2. The vascular walls in Intracranial aneurysm rat models produced high levels of SRPK1 expression and an activated PI3 K/Akt signaling pathway
      Title: SRPK1 gene silencing promotes vascular smooth muscle cell proliferation and vascular remodeling via inhibition of the PI3K/Akt signaling pathway in a rat model of intracranial aneurysms.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116186

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SRSF protein kinase 1
    Names
    SFRS protein kinase 1
    serine/arginine-rich protein specific kinase 1
    serine/threonine-protein kinase SRPK1
    NP_001020897.1
    XP_038954749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025726.1 → NP_001020897.1  SRSF protein kinase 1

      See identical proteins and their annotated locations for NP_001020897.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099089
      UniProtKB/TrEMBL
      A0A0U1RRU0, A0A9K3Y6Q8, E9PTN4, Q4KLN3
      Related
      ENSRNOP00000000612.8, ENSRNOT00000000612.9
      Conserved Domains (2) summary
      smart00220
      Location:80 → 224
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:70 → 653
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6647539..6684129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098821.2 → XP_038954749.1  SRSF protein kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RRU0
      Conserved Domains (1) summary
      cl21453
      Location:1 → 546
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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