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    Hnrnpa3 heterogeneous nuclear ribonucleoprotein A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362152, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hnrnpa3provided by RGD
    Official Full Name
    heterogeneous nuclear ribonucleoprotein A3provided by RGD
    Primary source
    RGD:727807
    See related
    EnsemblRapid:ENSRNOG00000052968 AllianceGenome:RGD:727807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    mBx; Hnrpa3
    Summary
    Enables RNA transmembrane transporter activity and mRNA binding activity. Involved in mRNA transport. Located in ribonucleoprotein granule. Part of ribonucleoprotein complex. Is active in glutamatergic synapse and postsynaptic density. Biomarker of silicosis. Orthologous to human HNRNPA3 (heterogeneous nuclear ribonucleoprotein A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 585.1), Spleen (RPKM 439.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hnrnpa3 in Genome Data Viewer
    Location:
    3q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (80984470..80999413)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (60578574..60588755)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (62481222..62491356)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101577 Neighboring gene uncharacterized LOC134486117 Neighboring gene uncharacterized LOC102554564 Neighboring gene NFE2 like bZIP transcription factor 2 Neighboring gene ribosomal protein L10, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a murine, major A/B type hnRNP protein: mBx. Plomaritoglou A, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786617
    2. [Differential analysis of two-dimensional gel electrophoresis profiles in lung tissue of rats exposed to silica early]. Chen JJ, et al. Zhonghua Yu Fang Yi Xue Za Zhi, 2009 May. PMID 19534998
    3. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. Mori K, et al. EMBO Rep, 2016 Sep. PMID 27461252, Free PMC Article
    4. Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. Percipalle P, et al. Nucleic Acids Res, 2002 Apr 15. PMID 11937625, Free PMC Article
    5. Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein. Ma AS, et al. J Biol Chem, 2002 May 17. PMID 11886857

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurons in the hippocampus of C9orf72 patients are frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the hippocampus of patients with extended C9orf72 repeats correlates with increased DPR deposition.
      Title: Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
    2. has a role in cytoplasmic trafficking of RNA (heterogenous nuclear ribonucleoprotein A3)
      Title: Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein A3
    Names
    hnRNP A3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111294.1 → NP_001104764.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

      See identical proteins and their annotated locations for NP_001104764.1

      Status: VALIDATED

      Source sequence(s)
      AT006305, AW534817, BC081878, BI292197, BP488086, CB585714, CF110612, CF110891, CV107265, CV109437
      UniProtKB/Swiss-Prot
      Q6URK3, Q6URK4
      UniProtKB/TrEMBL
      A6HME5, D4A6A2
      Related
      ENSRNOP00000079420.2, ENSRNOT00000097068.2
      Conserved Domains (3) summary
      pfam11627
      Location:332 → 348
      HnRNPA1; Nuclear factor hnRNPA1
      cd12578
      Location:36 → 113
      RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cd12582
      Location:126 → 205
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    2. NM_001111295.1 → NP_001104765.1  heterogeneous nuclear ribonucleoprotein A3 isoform b

      See identical proteins and their annotated locations for NP_001104765.1

      Status: VALIDATED

      Source sequence(s)
      BC081878, CB585714, CB725005
      UniProtKB/TrEMBL
      A6HME9, D4A6A2
      Conserved Domains (3) summary
      pfam11627
      Location:310 → 326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:104 → 183
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12763
      Location:11 → 91
      RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    3. NM_198132.3 → NP_937765.1  heterogeneous nuclear ribonucleoprotein A3 isoform a

      See identical proteins and their annotated locations for NP_937765.1

      Status: VALIDATED

      Source sequence(s)
      BC081878, CB585714
      UniProtKB/Swiss-Prot
      Q6URK3, Q6URK4
      UniProtKB/TrEMBL
      A6HME5, D4A6A2
      Conserved Domains (3) summary
      pfam11627
      Location:332 → 348
      HnRNPA1; Nuclear factor hnRNPA1
      cd12578
      Location:36 → 113
      RRM1_hnRNPA_like; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A subfamily
      cd12582
      Location:126 → 205
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      80984470..80999413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284131.1 → XP_063140201.1  heterogeneous nuclear ribonucleoprotein A3 isoform X1

      UniProtKB/Swiss-Prot
      Q6URK3, Q6URK4
      UniProtKB/TrEMBL
      A6HME5

    2. XM_063284134.1 → XP_063140204.1  heterogeneous nuclear ribonucleoprotein A3 isoform X3

      UniProtKB/TrEMBL
      A6HME9

    3. XM_063284132.1 → XP_063140202.1  heterogeneous nuclear ribonucleoprotein A3 isoform X2

    4. XM_008761911.4 → XP_008760133.1  heterogeneous nuclear ribonucleoprotein A3 isoform X3

      See identical proteins and their annotated locations for XP_008760133.1

      UniProtKB/TrEMBL
      A6HME9, D4A6A2
      Conserved Domains (3) summary
      pfam11627
      Location:310 → 326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:104 → 183
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12763
      Location:11 → 91
      RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

    5. XM_008761912.4 → XP_008760134.1  heterogeneous nuclear ribonucleoprotein A3 isoform X3

      See identical proteins and their annotated locations for XP_008760134.1

      UniProtKB/TrEMBL
      A6HME9, D4A6A2
      Conserved Domains (3) summary
      pfam11627
      Location:310 → 326
      HnRNPA1; Nuclear factor hnRNPA1
      cd12582
      Location:104 → 183
      RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
      cd12763
      Location:11 → 91
      RRM1_hnRNPA3; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6URK4.1 GenPept UniProtKB/Swiss-Prot:Q6URK4

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