Zbtb7b zinc finger and BTB domain containing 7B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zbtb7bprovided by RGD
Official Full Name: zinc finger and BTB domain containing 7Bprovided by RGD
Primary source: RGD:1305963
See related: EnsemblRapid:ENSRNOG00000020640 AllianceGenome:RGD:1305963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp67
Summary: Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of signal transduction; regulation of alpha-beta T cell activation; and regulation of gene expression. Predicted to act upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Predicted to be located in nucleoplasm. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 135.7), Adrenal (RPKM 122.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177093569..177111894, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174795831..174811980, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188704989..188719674, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in NK T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in adaptive thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in lactation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SREBP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of CD8-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T-helper cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger and BTB domain-containing protein 7B

Names: zinc finger protein 67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106446.1 → NP_001099916.1 zinc finger and BTB domain-containing protein 7B

See identical proteins and their annotated locations for NP_001099916.1

Status: PROVISIONAL

Source sequence(s)

CH473976

UniProtKB/TrEMBL

A6J6F5

Conserved Domains (3) summary

COG5048
Location:232 → 311

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:263 → 283

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:250 → 272

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177093569..177111894 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008761136.4 → XP_008759358.1 zinc finger and BTB domain-containing protein 7B isoform X2

See identical proteins and their annotated locations for XP_008759358.1

UniProtKB/TrEMBL

D4A579

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:367 → 389

zf-H2C2_2; Zinc-finger double domain
XM_006232614.5 → XP_006232676.1 zinc finger and BTB domain-containing protein 7B isoform X2

See identical proteins and their annotated locations for XP_006232676.1

UniProtKB/TrEMBL

D4A579

Related

ENSRNOP00000028010.7, ENSRNOT00000028010.9

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:367 → 389

zf-H2C2_2; Zinc-finger double domain
XM_008761137.4 → XP_008759359.1 zinc finger and BTB domain-containing protein 7B isoform X2

See identical proteins and their annotated locations for XP_008759359.1

UniProtKB/TrEMBL

D4A579

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:367 → 389

zf-H2C2_2; Zinc-finger double domain
XM_039102042.2 → XP_038957970.1 zinc finger and BTB domain-containing protein 7B isoform X1

Conserved Domains (4) summary

COG5048
Location:403 → 482

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:434 → 454

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:63 → 196

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:421 → 443

zf-H2C2_2; Zinc-finger double domain
XM_017590764.3 → XP_017446253.1 zinc finger and BTB domain-containing protein 7B isoform X2

UniProtKB/TrEMBL

D4A579

Conserved Domains (4) summary

COG5048
Location:349 → 428

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:380 → 400

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18327
Location:9 → 142

BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)

pfam13465
Location:367 → 389

zf-H2C2_2; Zinc-finger double domain