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    Ssx2ip SSX family member 2 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308023, updated on 9-Dec-2024

    Summary

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    Symbol
    Ssx2ipprovided by RGD
    Full Name
    SSX family member 2 interacting proteinprovided by RGD
    Primary source
    RGD:708490
    See related
    EnsemblRapid:ENSRNOG00000015425 AllianceGenome:RGD:708490
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ADIP
    Summary
    Enables protein domain specific binding activity. Predicted to be involved in centrosome cycle and intraciliary transport involved in cilium assembly. Predicted to act upstream of or within regulation of Rac protein signal transduction and regulation of cell motility. Located in adherens junction. Orthologous to human SSX2IP (SSX family member 2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 931.5), Testes (RPKM 159.8) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ssx2ip in Genome Data Viewer
    Location:
    2q44
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (237958286..237991026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235298012..235330750)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252263323..252296049)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid receptor 3 Neighboring gene RNA, U6 small nuclear 777 Neighboring gene chitobiase Neighboring gene spermatogenesis associated 1 Neighboring gene uncharacterized LOC134485993 Neighboring gene G protein subunit gamma 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Afadin regulates RhoA/Rho-associated protein kinase signaling to control formation of actin stress fibers in kidney podocytes. Saito K, et al. Cytoskeleton (Hoboken), 2015 Mar. PMID 25712270
    2. The centriolar satellite protein SSX2IP promotes centrosome maturation. Bärenz F, et al. J Cell Biol, 2013 Jul 8. PMID 23816619, Free PMC Article
    3. Afadin- and alpha-actinin-binding protein ADIP directly binds beta'-COP, a subunit of the coatomer complex. Asada M, et al. Biochem Biophys Res Commun, 2004 Aug 20. PMID 15358183
    4. The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone. Klinger M, et al. Mol Biol Cell, 2014 Feb. PMID 24356449, Free PMC Article
    5. ADIP, a novel Afadin- and alpha-actinin-binding protein localized at cell-cell adherens junctions. Asada M, et al. J Biol Chem, 2003 Feb 7. PMID 12446711

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. afadin mediates RhoA/ROCK signaling and contributes to the formation of actin stress fibers in podocyte cells
      Title: Afadin regulates RhoA/Rho-associated protein kinase signaling to control formation of actin stress fibers in kidney podocytes.
    2. ADIP is involved in vesicle trafficking from the Golgi to the endoplasmic reticulum
      Title: Afadin- and alpha-actinin-binding protein ADIP directly binds beta'-COP, a subunit of the coatomer complex.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rac protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell leading edge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriolar satellite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    afadin- and alpha-actinin-binding protein
    Names
    afadin DIL domain-interacting protein
    afadin- and alpha-actinin-binding protein ADIP
    afadin- and alpha-actinin-binding protein-like
    synovial sarcoma, X breakpoint 2 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175597.3 → NP_783187.1  afadin- and alpha-actinin-binding protein

      See identical proteins and their annotated locations for NP_783187.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078687
      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5
      Conserved Domains (2) summary
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      237958286..237991026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233454.5 → XP_006233516.1  afadin- and alpha-actinin-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006233516.1

      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5
      Conserved Domains (2) summary
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    2. XM_006233455.5 → XP_006233517.1  afadin- and alpha-actinin-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006233517.1

      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5
      Related
      ENSRNOP00000072590.3, ENSRNOT00000084034.3
      Conserved Domains (2) summary
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    3. XM_039102140.2 → XP_038958068.1  afadin- and alpha-actinin-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5
      Conserved Domains (2) summary
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    4. XM_063281685.1 → XP_063137755.1  afadin- and alpha-actinin-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5
      Related
      ENSRNOP00000043877.3, ENSRNOT00000041186.7

    5. XM_063281686.1 → XP_063137756.1  afadin- and alpha-actinin-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5

    6. XM_039102141.2 → XP_038958069.1  afadin- and alpha-actinin-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8CGZ2
      UniProtKB/TrEMBL
      A6HWD4, A6HWD5
      Conserved Domains (2) summary
      pfam17380
      Location:140 → 301
      DUF5401; Family of unknown function (DUF5401)
      pfam11559
      Location:63 → 214
      ADIP; Afadin- and alpha -actinin-Binding

    7. XM_006233458.5 → XP_006233520.2  afadin- and alpha-actinin-binding protein isoform X2

      UniProtKB/TrEMBL
      A6HWD5
      Related
      ENSRNOP00000101432.1, ENSRNOT00000144435.1
      Conserved Domains (2) summary
      pfam17380
      Location:25 → 183
      DUF5401; Family of unknown function (DUF5401)
      cl23720
      Location:25 → 96
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGZ2.1 GenPept UniProtKB/Swiss-Prot:Q8CGZ2

    Gene LinkOut

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