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    Znhit6 zinc finger, HIT-type containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Znhit6provided by RGD
    Official Full Name
    zinc finger, HIT-type containing 6provided by RGD
    Primary source
    RGD:1308723
    See related
    EnsemblRapid:ENSRNOG00000030049 AllianceGenome:RGD:1308723
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308723
    Summary
    Predicted to enable ATPase binding activity; TFIID-class transcription factor complex binding activity; and identical protein binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein-containing complex assembly; and snoRNA localization. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Orthologous to human ZNHIT6 (zinc finger HIT-type containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 36.4), Adrenal (RPKM 32.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Znhit6 in Genome Data Viewer
    Location:
    2q44
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (237147014..237178279)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (234486686..234517952)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (251453503..251484760)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene collagen type XXIV alpha 1 chain Neighboring gene uncharacterized LOC134485997 Neighboring gene uncharacterized LOC134485996 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102553018 Neighboring gene cellular communication network factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A dynamic scaffold of pre-snoRNP factors facilitates human box C/D snoRNP assembly. McKeegan KS, et al. Mol Cell Biol, 2007 Oct. PMID 17636026, Free PMC Article
    2. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article
    3. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box C/D snoRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snoRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pre-snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pre-snoRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    box C/D snoRNA protein 1
    Names
    zinc finger, HIT type 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106203.2 → NP_001099673.1  box C/D snoRNA protein 1

      See identical proteins and their annotated locations for NP_001099673.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161957
      UniProtKB/TrEMBL
      A0A8I5ZXU8, B1WC05, F7F2A4
      Related
      ENSRNOP00000041785.3, ENSRNOT00000041897.5
      Conserved Domains (1) summary
      pfam04438
      Location:208 → 237
      zf-HIT; HIT zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      237147014..237178279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101880.2 → XP_038957808.1  box C/D snoRNA protein 1 isoform X3

      UniProtKB/TrEMBL
      A6HWB9

    2. XM_039101877.2 → XP_038957805.1  box C/D snoRNA protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZXU8
      Related
      ENSRNOP00000092127.2, ENSRNOT00000098863.2
      Conserved Domains (1) summary
      pfam04438
      Location:208 → 237
      zf-HIT; HIT zinc finger

    3. XM_039101879.2 → XP_038957807.1  box C/D snoRNA protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GII8, A6HWB7, A6HWB8
      Conserved Domains (1) summary
      pfam04438
      Location:64 → 93
      zf-HIT; HIT zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version

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