U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tpte2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364629, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Symbol
    Tpte2provided by RGD
    Full Name
    transmembrane phosphoinositide 3-phosphatase and tensin homolog 2provided by RGD
    Primary source
    RGD:1305825
    See related
    EnsemblRapid:ENSRNOG00000024837 AllianceGenome:RGD:1305825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tpte
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 30.3) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tpte2 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (76361330..76455664, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69658874..69756571, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74552859..74662194, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S31 Neighboring gene uncharacterized LOC120097532 Neighboring gene solute carrier family 25 member 15 Neighboring gene lncRNA derived from hepatocytes Neighboring gene SUB1 regulator of transcription, pseudogene 2 Neighboring gene transfer RNA alanine (anticodon AGC) 82 Neighboring gene thrombospondin type 1 domain containing 1 Neighboring gene vacuolar protein sorting 36 homolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. TPIP: a novel phosphoinositide 3-phosphatase. Walker SM, et al. Biochem J, 2001 Dec 1. PMID 11716755, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
    Names
    transmembrane phosphatase with tensin homology
    NP_001406113.1
    NP_001406114.1
    XP_017455690.2
    XP_017455691.1
    XP_038950664.1
    XP_063131690.1
    XP_063131691.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419184.1 → NP_001406113.1  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW76, D4ADC8

    2. NM_001419185.1 → NP_001406114.1  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6IW76, D4ADC8
      Related
      ENSRNOP00000029743.6, ENSRNOT00000034670.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      76361330..76455664 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094736.2 → XP_038950664.1  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 isoform X2

      UniProtKB/TrEMBL
      A6IW76
      Conserved Domains (2) summary
      cd14510
      Location:347 → 523
      PTP_VSP_TPTE; protein tyrosine phosphatase-like catalytic domain of voltage-sensitive phosphatase/transmembrane phosphatase with tensin homology
      pfam10409
      Location:532 → 666
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    2. XM_017600201.3 → XP_017455690.2  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 isoform X3

      UniProtKB/TrEMBL
      A6IW76
      Conserved Domains (2) summary
      cd14510
      Location:332 → 508
      PTP_VSP_TPTE; protein tyrosine phosphatase-like catalytic domain of voltage-sensitive phosphatase/transmembrane phosphatase with tensin homology
      pfam10409
      Location:517 → 651
      PTEN_C2; C2 domain of PTEN tumor-suppressor protein

    3. XM_063275620.1 → XP_063131690.1  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 isoform X1

      UniProtKB/TrEMBL
      A6IW76

    4. XM_063275621.1 → XP_063131691.1  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 isoform X3

      UniProtKB/TrEMBL
      A6IW76

    5. XM_017600202.2 → XP_017455691.1  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108877.1: Suppressed sequence

      Description
      NM_001108877.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.