Pfdn2 prefoldin subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pfdn2provided by RGD
Official Full Name: prefoldin subunit 2provided by RGD
Primary source: RGD:1591406
See related: EnsemblRapid:ENSRNOG00000083250 AllianceGenome:RGD:1591406
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable amyloid-beta binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in negative regulation of amyloid fibril formation; positive regulation of cytoskeleton organization; and protein folding. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be part of RPAP3/R2TP/prefoldin-like complex and prefoldin complex. Predicted to be active in cytoplasm. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 72.9), Adrenal (RPKM 59.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86305037..86323008)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83772301..83791367)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89725113..89743849)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE118958 (e-PCR)
- UniSTS:248914

BF387362 (e-PCR)
- UniSTS:244320

D1S2071E (e-PCR)
- UniSTS:151660

PMC21147P2 (e-PCR)
- UniSTS:272016

W57327 (e-PCR), detects polymorphism
- UniSTS:143016

RH128828 (e-PCR)
- UniSTS:212136

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RPAP3/R2TP/prefoldin-like complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prefoldin subunit 2

Names: prefoldin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.