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    Gtf2h3 general transcription factor IIH subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288651, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gtf2h3provided by RGD
    Official Full Name
    general transcription factor IIH subunit 3provided by RGD
    Primary source
    RGD:1305494
    See related
    EnsemblRapid:ENSRNOG00000001035 AllianceGenome:RGD:1305494
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in nucleotide-excision repair and transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of core TFIIH complex portion of holo TFIIH complex; transcription factor TFIID complex; and transcription preinitiation complex. Orthologous to human GTF2H3 (general transcription factor IIH subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 109.3), Spleen (RPKM 79.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gtf2h3 in Genome Data Viewer
    Location:
    12q15
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37669995..37687505, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (32009010..32025484, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37427556..37444027, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tectonic family member 2 Neighboring gene transfer RNA alanine (anticodon AGC) 44 Neighboring gene translocase of inner mitochondrial membrane 23, pseudogene 1 Neighboring gene eukaryotic translation initiation factor 2B subunit alpha Neighboring gene DEAD-box helicase 55 Neighboring gene transmembrane p24 trafficking protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of core TFIIH complex portion of holo TFIIH complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of core TFIIH complex portion of holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of core TFIIH complex portion of holo TFIIH complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription factor TFIID complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription factor TFIIH holo complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    general transcription factor IIH subunit 3
    Names
    general transcription factor IIH, polypeptide 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024236.1NP_001019407.1  general transcription factor IIH subunit 3

      See identical proteins and their annotated locations for NP_001019407.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093380
      UniProtKB/Swiss-Prot
      Q561R7
      UniProtKB/TrEMBL
      A0A8I6ASU2, A6J0Y2
      Related
      ENSRNOP00000001368.4, ENSRNOT00000001368.8
      Conserved Domains (1) summary
      TIGR00627
      Location:7290
      tfb4; transcription factor tfb4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      37669995..37687505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271173.1XP_063127243.1  general transcription factor IIH subunit 3 isoform X1

      UniProtKB/Swiss-Prot
      Q561R7
      UniProtKB/TrEMBL
      A6J0Y2