Scarb1 scavenger receptor class B, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scarb1provided by RGD
Official Full Name: scavenger receptor class B, member 1provided by RGD
Primary source: RGD:2302
See related: EnsemblRapid:ENSRNOG00000000981 AllianceGenome:RGD:2302
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Srb1; SR-B1; Cd36l1
Summary: Enables identical protein binding activity and phosphatidylserine binding activity. Involved in several processes, including androgen biosynthetic process; recognition of apoptotic cell; and response to vitamin B3. Located in cell surface and microvillus membrane. Biomarker of end stage renal disease. Orthologous to human SCARB1 (scavenger receptor class B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 3363.7), Liver (RPKM 262.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (36957302..37023982)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (31296143..31362649)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (36694952..36761445)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The molecular docking revealed that S-allyl-mercapto-glutathione interacting with Colec12, MARCO (class A), and SCARB1 (class B) scavenger receptors in in vitro tests demonstrates a direct stimulation of immunoglobulin secretion by S-allylmercaptoglutathione (GSSA) in CD19+ B lymphocytes.
Title: New Aspects Towards a Molecular Understanding of the Allicin Immunostimulatory Mechanism via Colec12, MARCO, and SCARB1 Receptors.
Taken together, DEHP-disturbed HPT axis and induced 5alpha-Reductase 2 contribute to the reduction of serum testosterone level. The activated ERK pathway is required to modulate expressions of 5alpha-Reductase 2 and SRB1.
Title: Di-(2-ethylhexyl) phthalate inhibits testosterone level through disturbed hypothalamic-pituitary-testis axis and ERK-mediated 5α-Reductase 2.
The results suggest that NHERF1 and NHERF2 down-regulated SR-B1 at least in part via the ubiquitin/proteasome pathway.
Title: NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation.
Model recombinant HDL (rHDL) particles formed in vitro with S1P incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P did not, suggesting that S1P transported in HDL can selectively activate S1PR1.
Title: S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization.
Chronic vitamin A-enriched diet feeding decreased hypercholesterolaemia and normalized HDL-C levels, possibly by regulating pathways involved in HDL synthesis and degradation, independent of hepatic SR-B1 in this glucose-intolerant obese rat mode
Title: Chronic vitamin A-enriched diet feeding regulates hypercholesterolaemia through transcriptional regulation of reverse cholesterol transport pathway genes in obese rat model of WNIN/GR-Ob strain.
role for SIK1 in the positive regulation of selective HDL-CE transport function of SR-B1 and steroidogenesis
Title: A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity.
SR-B1 may be involved in uterine function, follicular development as well as luteal function.
Title: Expression and regulation of scavenger receptor class B type 1 in the rat ovary and uterus during the estrous cycle.
data establish NHERF1 and NHERF2 as SR-BI protein binding partners that play a negative role in the regulation of SR-BI expression, selective CE transport, and steroidogenesis.
Title: Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs).
ovarian granulosa cells retain the cholesterol homeostatic control machinery like nonsteroidogenic cells, although during active steroidogenesis, they utilize SR-BI to evade such feedback control
Title: Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis.
Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps.
Title: Characterization of hepatitis C virus particle subpopulations reveals multiple usage of the scavenger receptor BI for entry steps.

Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

RH130563 (e-PCR)
- UniSTS:213847

RH134480 (e-PCR)
- UniSTS:217760

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein A-I binding	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor activity	IEA Inferred from Electronic Annotation more info
enables high-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info
enables high-density lipoprotein particle receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	TAS Traceable Author Statement more info	PubMed
enables lipopolysaccharide binding	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide immune receptor activity	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide immune receptor activity	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	IBA Inferred from Biological aspect of Ancestor more info
enables low-density lipoprotein particle binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	TAS Traceable Author Statement more info	PubMed
enables scavenger receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adhesion of symbiont to host	IEA Inferred from Electronic Annotation more info
involved_in aflatoxin metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in androgen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in cholesterol catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol import	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol import	IEA Inferred from Electronic Annotation more info
involved_in cholesterol import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in detection of lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in detection of lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in intestinal lipid absorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipopolysaccharide transport	IEA Inferred from Electronic Annotation more info
involved_in lipopolysaccharide transport	ISO Inferred from Sequence Orthology more info
involved_in lipopolysaccharide-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle clearance	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in plasma lipoprotein particle clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cholesterol storage	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cholesterol storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol storage	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in recognition of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in recognition of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in recognition of apoptotic cell	IEA Inferred from Electronic Annotation more info
involved_in recognition of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in recognition of apoptotic cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in regulation of phosphatidylcholine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin B3	IEP Inferred from Expression Pattern more info	PubMed
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in reverse cholesterol transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in steroid biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in transcytosis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in vitamin transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vitamin transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: scavenger receptor class B member 1

Names: CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; SR-BI; scavanger receptor class B type 1; scavenger receptor class B type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031541.2 → NP_113729.1 scavenger receptor class B member 1

See identical proteins and their annotated locations for NP_113729.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P97943

UniProtKB/TrEMBL

A6J0X1, Q6SR89

Related

ENSRNOP00000085701.1, ENSRNOT00000110392.2

Conserved Domains (1) summary

pfam01130
Location:21 → 447

CD36; CD36 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

36957302..37023982

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598269.3 → XP_017453758.1 scavenger receptor class B member 1 isoform X1

UniProtKB/TrEMBL

A6J0X0, G3V636, Q6B4I7

Related

ENSRNOP00000001299.5, ENSRNOT00000001299.9

Conserved Domains (1) summary

pfam01130
Location:21 → 447

CD36; CD36 family