Spag6l sperm associated antigen 6-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spag6lprovided by RGD
Official Full Name: sperm associated antigen 6-likeprovided by RGD
Primary source: RGD:1310892
See related: EnsemblRapid:ENSRNOG00000025787 AllianceGenome:RGD:1310892
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Spag6; RGD1310892
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to act upstream of or within several processes, including cilium assembly; epithelial cilium movement involved in extracellular fluid movement; and stress fiber assembly. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and lateral wall of outer hair cell. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 462.8) and Lung (RPKM 71.4) See more
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Genomic context

Location:: 11q23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (97677840..97773580)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (84173628..84269374)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (88424493..88517910)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Function of Spag6 to Repair Brain Edema Damage After Cerebral Ischemic Stroke-reperfusion.
Title: The Function of Spag6 to Repair Brain Edema Damage After Cerebral Ischemic Stroke-reperfusion.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebrospinal fluid circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ear development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mucociliary clearance	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection extension	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cilium beat frequency	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of planar polarity	ISO Inferred from Sequence Orthology more info
involved_in sperm axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sperm axoneme assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within stress fiber assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate-dependent cell migration, cell attachment to substrate	ISO Inferred from Sequence Orthology more info
acts_upstream_of ventricular system development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in axonemal central apparatus	ISO Inferred from Sequence Orthology more info
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lateral wall of outer hair cell	ISO Inferred from Sequence Orthology more info
located_in manchette	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sperm principal piece	IBA Inferred from Biological aspect of Ancestor more info
located_in sperm principal piece	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sperm-associated antigen 6

Names: sperm associated antigen 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034960.1 → NP_001030132.1 sperm-associated antigen 6

See identical proteins and their annotated locations for NP_001030132.1

Status: PROVISIONAL

Source sequence(s)

BC104678

UniProtKB/TrEMBL

A6JSP6, Q3MHU1

Related

ENSRNOP00000088293.1, ENSRNOT00000106349.2

Conserved Domains (4) summary

cd00020
Location:161 → 279

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam13646
Location:130 → 234

HEAT_2; HEAT repeats

sd00044
Location:85 → 109

HEAT; HEAT repeat [structural motif]

sd00043
Location:120 → 152

ARM; armadillo repeat [structural motif]