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    Coro6 coronin 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 245982, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Coro6provided by RGD
    Official Full Name
    coronin 6provided by RGD
    Primary source
    RGD:708560
    See related
    EnsemblRapid:ENSRNOG00000014496 AllianceGenome:RGD:708560
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. Orthologous to human CORO6 (coronin 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 190.7), Heart (RPKM 139.0) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Coro6 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (62808172..62817788)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62311552..62319659)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (62691952..62700658, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene EF-hand calcium binding domain 5 Neighboring gene slingshot protein phosphatase 2 Neighboring gene uncharacterized LOC134480826 Neighboring gene uncharacterized LOC120095265 Neighboring gene ankyrin repeat domain 13B Neighboring gene GIT ArfGAP 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton. Chen Y, et al. J Neurosci, 2014 Feb 12. PMID 24523531, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    3. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these findings demonstrate that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the neuromuscular junction
      Title: Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112600

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coronin-6
    Names
    clipin E
    coronin relative protein
    coronin, actin binding protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139115.2 → NP_620815.2  coronin-6

      Status: PROVISIONAL

      Source sequence(s)
      BC098656
      UniProtKB/Swiss-Prot
      Q4G087, Q920J3
      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 466
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 386
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      62808172..62817788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246886.5 → XP_006246948.1  coronin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWB1
      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 466
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 386
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006246888.5 → XP_006246950.1  coronin-6 isoform X4

      UniProtKB/TrEMBL
      A6HGX5
      Related
      ENSRNOP00000083587.2, ENSRNOT00000118502.2
      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 465
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 386
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006246885.5 → XP_006246947.1  coronin-6 isoform X1

      UniProtKB/Swiss-Prot
      Q4G087, Q920J3
      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 466
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 386
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_006246887.5 → XP_006246949.1  coronin-6 isoform X3

      UniProtKB/TrEMBL
      A6HGX6
      Related
      ENSRNOP00000019759.4, ENSRNOT00000019759.8
      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 465
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:344 → 386
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_006246889.5 → XP_006246951.1  coronin-6 isoform X5

      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 426
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:304 → 346
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 258
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_006246890.5 → XP_006246952.1  coronin-6 isoform X6

      UniProtKB/TrEMBL
      A0A8L2RAN5, A6HGX7
      Related
      ENSRNOP00000075615.2, ENSRNOT00000086706.3
      Conserved Domains (5) summary
      PTZ00421
      Location:9 → 425
      PTZ00421; coronin; Provisional
      pfam08953
      Location:7 → 64
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:304 → 346
      WD40_4; Type of WD40 repeat
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:78 → 258
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_005489689.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q920J3.2 GenPept UniProtKB/Swiss-Prot:Q920J3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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