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    Nek8 NIMA-related kinase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287473, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nek8provided by RGD
    Official Full Name
    NIMA-related kinase 8provided by RGD
    Primary source
    RGD:1306897
    See related
    EnsemblRapid:ENSRNOG00000012866 AllianceGenome:RGD:1306897
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in animal organ morphogenesis and regulation of hippo signaling. Predicted to act upstream of or within determination of left/right symmetry and heart development. Predicted to be located in ciliary base and ciliary inversin compartment. Predicted to be active in cilium. Used to study nephronophthisis 9. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 31.0), Spleen (RPKM 15.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nek8 in Genome Data Viewer
    Location:
    10q25
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63558940..63570954, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (63060868..63073546, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (65404489..65439059, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480829 Neighboring gene family with sequence similarity 222, member B Neighboring gene Tnf receptor associated factor 4 Neighboring gene small nucleolar RNA, C/D box 42A Neighboring gene TLC domain containing 1 Neighboring gene ribosomal protein L23A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. McCooke JK, et al. BMC Genomics, 2012 Aug 16. PMID 22899815, Free PMC Article
    2. Mutations in NEK8 link multiple organ dysplasia with altered Hippo signalling and increased c-MYC expression. Frank V, et al. Hum Mol Genet, 2013 Jun 1. PMID 23418306
    3. NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. Otto EA, et al. J Am Soc Nephrol, 2008 Mar. PMID 18199800, Free PMC Article
    4. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. Mahjoub MR, et al. J Am Soc Nephrol, 2005 Dec. PMID 16267153
    5. Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia. Shiba D, et al. Cytoskeleton (Hoboken), 2010 Feb. PMID 20169535, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel Nek8 mutation R650C is that occurs within the regulator of chromosome condensation 1 (RCC1)-like region of the protein.
      Title: A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary inversin compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek8
    Names
    NIMA (never in mitosis gene a)- related kinase 8
    NIMA (never in mitosis gene a)-related expressed kinase 8
    never in mitosis A-related kinase 8
    nimA-related protein kinase 8
    NP_001099274.1
    XP_038941422.1
    XP_038941424.1
    XP_038941426.1
    XP_038941427.1
    XP_063124741.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105804.2 → NP_001099274.1  serine/threonine-protein kinase Nek8

      See identical proteins and their annotated locations for NP_001099274.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZGQ5
      UniProtKB/TrEMBL
      A0A8I5ZRU5
      Related
      ENSRNOP00000079841.1, ENSRNOT00000101809.2
      Conserved Domains (2) summary
      COG5184
      Location:318 → 663
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:3 → 258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63558940..63570954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085494.2 → XP_038941422.1  serine/threonine-protein kinase Nek8 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRU5
      Related
      ENSRNOP00000017264.6, ENSRNOT00000017264.8
      Conserved Domains (2) summary
      COG5184
      Location:318 → 663
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:3 → 258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8

    2. XM_063268671.1 → XP_063124741.1  serine/threonine-protein kinase Nek8 isoform X3

    3. XM_039085496.2 → XP_038941424.1  serine/threonine-protein kinase Nek8 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZRU5
      Conserved Domains (2) summary
      COG5184
      Location:318 → 663
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:3 → 258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8

    4. XM_039085498.2 → XP_038941426.1  serine/threonine-protein kinase Nek8 isoform X4

      Conserved Domains (2) summary
      COG5184
      Location:312 → 479
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:3 → 258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8

    5. XM_039085499.2 → XP_038941427.1  serine/threonine-protein kinase Nek8 isoform X5

      Conserved Domains (2) summary
      COG5184
      Location:312 → 479
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd08220
      Location:3 → 258
      STKc_Nek8; Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8

    RNA

    1. XR_005489740.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZGQ5.1 GenPept UniProtKB/Swiss-Prot:D3ZGQ5

    Gene LinkOut

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