U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mrpl22 mitochondrial ribosomal protein L22 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287302, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Mrpl22provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L22provided by RGD
    Primary source
    RGD:1309277
    See related
    EnsemblRapid:ENSRNOG00000027039 AllianceGenome:RGD:1309277
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL22 (mitochondrial ribosomal protein L22). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 243.7), Kidney (RPKM 237.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Mrpl22 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42843165..42856243)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42345446..42355779)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43601786..43612119)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene CCR4-NOT transcription complex, subunit 8 Neighboring gene gem (nuclear organelle) associated protein 5 Neighboring gene interferon gamma induced GTPase like 1 Neighboring gene uncharacterized LOC134480693

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
    2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    large ribosomal subunit protein uL22m
    Names
    39S ribosomal protein L22, mitochondrial
    L22mt
    MRP-L22

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105781.1 → NP_001099251.1  large ribosomal subunit protein uL22m precursor

      See identical proteins and their annotated locations for NP_001099251.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/Swiss-Prot
      P0C2C0
      UniProtKB/TrEMBL
      A0A8I6A4X1, A6HER4
      Conserved Domains (1) summary
      pfam00237
      Location:69 → 172
      Ribosomal_L22; Ribosomal protein L22p/L17e

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      42843165..42856243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268592.1 → XP_063124662.1  large ribosomal subunit protein uL22m isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHT3, A0A8I6A4X1

    2. XM_063268593.1 → XP_063124663.1  large ribosomal subunit protein uL22m isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHT3, A0A8I6A4X1
      Related
      ENSRNOP00000029336.5, ENSRNOT00000029238.7

    3. XM_063268594.1 → XP_063124664.1  large ribosomal subunit protein uL22m isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHT3, A0A8I6A4X1

    4. XM_063268595.1 → XP_063124665.1  large ribosomal subunit protein uL22m isoform X2

      UniProtKB/TrEMBL
      A6HER5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C2C0.1 GenPept UniProtKB/Swiss-Prot:P0C2C0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous