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    Rpl8 ribosomal protein L8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26962, updated on 9-Dec-2024

    Summary

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    Symbol
    Rpl8provided by RGD
    Full Name
    ribosomal protein L8provided by RGD
    Primary source
    RGD:619827
    See related
    AllianceGenome:RGD:619827
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 5.8S rRNA binding activity. Involved in cellular response to nerve growth factor stimulus. Part of cytosolic large ribosomal subunit. Orthologous to human RPL8 (ribosomal protein L8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 3946.9), Thymus (RPKM 3303.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpl8 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110506815..110509106)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108626194..108628485)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117967608..117969886)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5 Neighboring gene zinc finger protein 647 Neighboring gene Zinc finger protein 16 like, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The primary structure of rat ribosomal protein L8. Chan YL, et al. Biochem Biophys Res Commun, 1992 Jun 15. PMID 1610349
    2. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. Hanes J, et al. Biochem Biophys Res Commun, 1993 Dec 30. PMID 7506540
    3. Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins. Angelastro JM, et al. BMC Neurosci, 2002. PMID 11922865, Free PMC Article
    4. Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1979 Sep 10. PMID 468846
    5. Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins. Bayés A, et al. PLoS One, 2012. PMID 23071613, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC124745, MGC156485

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5.8S rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL2
    Names
    60S ribosomal protein L8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034916.3 → NP_001030088.2  large ribosomal subunit protein uL2

      See identical proteins and their annotated locations for NP_001030088.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      A0JMZ6, P62919
      UniProtKB/TrEMBL
      A6HSE3, A6HSE4
      Conserved Domains (1) summary
      cl40667
      Location:1 → 254
      RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      110506815..110509106
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62919.2 GenPept UniProtKB/Swiss-Prot:P62919

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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