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    CDC16 cell division cycle 16 [ Homo sapiens (human) ]

    Gene ID: 8881, updated on 27-Nov-2024

    Summary

    Official Symbol
    CDC16provided by HGNC
    Official Full Name
    cell division cycle 16provided by HGNC
    Primary source
    HGNC:HGNC:1720
    See related
    Ensembl:ENSG00000130177 MIM:603461; AllianceGenome:HGNC:1720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APC6; CUT9; ANAPC6; CDC16Hs
    Summary
    The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 21.1) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDC16 in Genome Data Viewer
    Location:
    13q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (114234897..114272723)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (113443956..113481783)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (115000372..115038198)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RAS p21 protein activator 3 Neighboring gene uncharacterized LOC107987192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114892696-114893197 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114895306-114895935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114897194-114897821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5557 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114900119-114900619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114906114-114907109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114916272-114916772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114916773-114917273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114927227-114928127 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114951001-114951592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114952186-114952777 Neighboring gene CFAP97 domain containing 2 Neighboring gene Sharpr-MPRA regulatory region 1096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:114993807-114994308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5558 Neighboring gene uncharacterized LOC105370384 Neighboring gene microRNA 548ar Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:115047057-115047744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5561 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:115049711-115049907 Neighboring gene uncharacterized LOC124903222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:115057299-115057800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:115057801-115058300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8064 Neighboring gene microRNA 4502 Neighboring gene UPF3A regulator of nonsense mediated mRNA decay

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of cell division cycle 16 homolog (S. cerevisiae) (CDC16) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cell division cycle protein 16 homolog
    Names
    anaphase-promoting complex, subunit 6
    cell division cycle 16 homolog
    cyclosome subunit 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001078645.3NP_001072113.1  cell division cycle protein 16 homolog isoform 1

      See identical proteins and their annotated locations for NP_001072113.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1 and 2 encode the same isoform (1) .
      Source sequence(s)
      AW662777, AW953481, BM663581, BQ051608, BQ424567, DC391369
      Consensus CDS
      CCDS9542.2
      UniProtKB/Swiss-Prot
      A2A365, Q13042, Q5T8C8, Q7Z651, Q96AE6, Q9Y564
      UniProtKB/TrEMBL
      B2RCW0
      Related
      ENSP00000348554.3, ENST00000356221.8
      Conserved Domains (5) summary
      COG3063
      Location:371511
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:10502
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:402430
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:447511
      TPR_12; Tetratricopeptide repeat
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    2. NM_001318517.3NP_001305446.1  cell division cycle protein 16 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice acceptor site in the 5' coding region and lacks an exon segment in the 3' UTR, compared to variant 2. Variants 3 and 5 encode the same isoform (2), which is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK315302, BM663581, DC391369, U18291
      Consensus CDS
      CCDS81786.1
      UniProtKB/TrEMBL
      B2RCW0
      Related
      ENSP00000252457.5, ENST00000252457.9
      Conserved Domains (5) summary
      sd00006
      Location:401429
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1593
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:446510
      TPR_12; Tetratricopeptide repeat
      cl26002
      Location:370510
      TPR_11; TPR repeat
      cl26860
      Location:336401
      PRK15359; type III secretion system chaperone protein SscB; Provisional
    3. NM_001318518.3NP_001305447.1  cell division cycle protein 16 homolog isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice acceptor site in the 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 2. These differences result in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AF164598, AK315302, BC050575, BM663581, DC391369
      UniProtKB/TrEMBL
      B2RCW0
      Related
      ENSP00000252458.6, ENST00000252458.6
      Conserved Domains (4) summary
      TIGR02917
      Location:133454
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:395421
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:395459
      TPR_12; Tetratricopeptide repeat
      pfam12895
      Location:1593
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
    4. NM_001330101.2NP_001317030.1  cell division cycle protein 16 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice acceptor site in the 5' coding region, compared to variant 2. Variants 3 and 5 encode the same isoform (2), which is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK315302, BC050575, BM663581, DC391369, U18291
      Consensus CDS
      CCDS81786.1
      UniProtKB/TrEMBL
      B2RCW0
      Conserved Domains (5) summary
      sd00006
      Location:401429
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1593
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13424
      Location:446510
      TPR_12; Tetratricopeptide repeat
      cl26002
      Location:370510
      TPR_11; TPR repeat
      cl26860
      Location:336401
      PRK15359; type III secretion system chaperone protein SscB; Provisional
    5. NM_001330104.2NP_001317033.1  cell division cycle protein 16 homolog isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4).
      Source sequence(s)
      BC050575, BM663581, BQ668939, BQ944893, CN401097, DC391369
      Consensus CDS
      CCDS81787.1
      UniProtKB/TrEMBL
      Q5T8C6
      Conserved Domains (4) summary
      COG3063
      Location:277417
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:40408
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:308336
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:353417
      TPR_12; Tetratricopeptide repeat
    6. NM_001330105.2NP_001317034.1  cell division cycle protein 16 homolog isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks a 5' exon and lacks an exon segment in the 3' UTR compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 6 and 7 encode the same isoform (4).
      Source sequence(s)
      BQ009960, BQ668939, BQ944893, CN401097, DC391369
      Consensus CDS
      CCDS81787.1
      UniProtKB/TrEMBL
      Q5T8C6
      Related
      ENSP00000364457.1, ENST00000375308.5
      Conserved Domains (4) summary
      COG3063
      Location:277417
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:40408
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:308336
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:353417
      TPR_12; Tetratricopeptide repeat
    7. NM_003903.5NP_003894.3  cell division cycle protein 16 homolog isoform 1

      See identical proteins and their annotated locations for NP_003894.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an exon segment in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      BQ051608, BQ424567, BU687000, DC391369
      Consensus CDS
      CCDS9542.2
      UniProtKB/Swiss-Prot
      A2A365, Q13042, Q5T8C8, Q7Z651, Q96AE6, Q9Y564
      UniProtKB/TrEMBL
      B2RCW0
      Related
      ENSP00000353549.3, ENST00000360383.7
      Conserved Domains (5) summary
      COG3063
      Location:371511
      PilF; Tfp pilus assembly protein PilF [Cell motility, Extracellular structures]
      TIGR02917
      Location:10502
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:402430
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:447511
      TPR_12; Tetratricopeptide repeat
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      114234897..114272723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534853.3XP_011533155.1  cell division cycle protein 16 homolog isoform X2

      UniProtKB/TrEMBL
      A0A3B3ISD2, B2RCW0
      Related
      ENSP00000497168.1, ENST00000650489.1
      Conserved Domains (4) summary
      smart00028
      Location:448478
      TPR; Tetratricopeptide repeats
      sd00006
      Location:447473
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:447509
      TPR_11; TPR repeat
    2. XM_005266206.3XP_005266263.1  cell division cycle protein 16 homolog isoform X6

      UniProtKB/TrEMBL
      B2RCW0
      Conserved Domains (5) summary
      smart00028
      Location:448478
      TPR; Tetratricopeptide repeats
      sd00006
      Location:402430
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:401476
      TPR_11; TPR repeat
      pfam13424
      Location:447509
      TPR_12; Tetratricopeptide repeat
    3. XM_011534851.3XP_011533153.1  cell division cycle protein 16 homolog isoform X1

      See identical proteins and their annotated locations for XP_011533153.1

      UniProtKB/TrEMBL
      B2RCW0
      Conserved Domains (5) summary
      smart00028
      Location:397427
      TPR; Tetratricopeptide repeats
      sd00006
      Location:396422
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:396458
      TPR_11; TPR repeat
      pfam13424
      Location:350421
      TPR_12; Tetratricopeptide repeat
    4. XM_047430755.1XP_047286711.1  cell division cycle protein 16 homolog isoform X7

    5. XM_047430756.1XP_047286712.1  cell division cycle protein 16 homolog isoform X8

    6. XM_047430754.1XP_047286710.1  cell division cycle protein 16 homolog isoform X5

    7. XM_017020831.3XP_016876320.1  cell division cycle protein 16 homolog isoform X3

      UniProtKB/TrEMBL
      B2RCW0
      Conserved Domains (4) summary
      smart00028
      Location:448478
      TPR; Tetratricopeptide repeats
      sd00006
      Location:447473
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:447509
      TPR_11; TPR repeat
    8. XM_017020830.3XP_016876319.1  cell division cycle protein 16 homolog isoform X1

      UniProtKB/TrEMBL
      B2RCW0
      Related
      ENSP00000486027.1, ENST00000628084.2
      Conserved Domains (5) summary
      smart00028
      Location:397427
      TPR; Tetratricopeptide repeats
      sd00006
      Location:396422
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:1594
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:396458
      TPR_11; TPR repeat
      pfam13424
      Location:350421
      TPR_12; Tetratricopeptide repeat
    9. XM_047430753.1XP_047286709.1  cell division cycle protein 16 homolog isoform X4

    10. XM_047430757.1XP_047286713.1  cell division cycle protein 16 homolog isoform X9

    11. XM_047430758.1XP_047286714.1  cell division cycle protein 16 homolog isoform X10

    RNA

    1. XR_001749714.3 RNA Sequence

    2. XR_245358.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      113443956..113481783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375145.1XP_054231120.1  cell division cycle protein 16 homolog isoform X2

      UniProtKB/TrEMBL
      A0A3B3ISD2
    2. XM_054375149.1XP_054231124.1  cell division cycle protein 16 homolog isoform X6

    3. XM_054375143.1XP_054231118.1  cell division cycle protein 16 homolog isoform X1

    4. XM_054375150.1XP_054231125.1  cell division cycle protein 16 homolog isoform X7

    5. XM_054375151.1XP_054231126.1  cell division cycle protein 16 homolog isoform X8

    6. XM_054375148.1XP_054231123.1  cell division cycle protein 16 homolog isoform X5

    7. XM_054375146.1XP_054231121.1  cell division cycle protein 16 homolog isoform X3

    8. XM_054375144.1XP_054231119.1  cell division cycle protein 16 homolog isoform X1

    9. XM_054375147.1XP_054231122.1  cell division cycle protein 16 homolog isoform X4

    10. XM_054375152.1XP_054231127.1  cell division cycle protein 16 homolog isoform X9

    11. XM_054375153.1XP_054231128.1  cell division cycle protein 16 homolog isoform X10

    RNA

    1. XR_008488793.1 RNA Sequence

    2. XR_008488794.1 RNA Sequence