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    PTPRS protein tyrosine phosphatase receptor type S [ Homo sapiens (human) ]

    Gene ID: 5802, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PTPRSprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase receptor type Sprovided by HGNC
    Primary source
    HGNC:HGNC:9681
    See related
    Ensembl:ENSG00000105426 MIM:601576; AllianceGenome:HGNC:9681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R-PTP-S; PTPSIGMA; PTP-sigma; R-PTP-sigma
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 30.9), brain (RPKM 23.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTPRS in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (5205508..5340812, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (5192102..5327425, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5205519..5340823, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4983945-4984871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4988552-4989057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4989058-4989562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4989779-4990280 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4990281-4990780 Neighboring gene Sharpr-MPRA regulatory region 13405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5004333-5004833 Neighboring gene lysine demethylase 4B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5026529-5027028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5036688-5037262 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5042227-5042746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5042747-5043265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5046625-5047428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5048922-5049524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5052015-5052514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5083429-5084111 Neighboring gene Sharpr-MPRA regulatory region 3293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5092687-5093236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5093237-5093784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5096761-5097261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5096260-5096760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5095749-5096249 Neighboring gene Sharpr-MPRA regulatory region 7356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5109710-5110566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5111029-5111538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5114178-5115133 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5115134-5116088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5121454-5121994 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5125360-5125896 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5125897-5126434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5126435-5126971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5126972-5127509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5128585-5129120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5129121-5129658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5129659-5130195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5130196-5130732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5130733-5131269 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5137253-5137754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5137755-5138254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13797 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5151275-5152046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5153977-5154477 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5165571-5165790 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:5172675-5173874 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5173956-5174147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13799 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:5191478-5192140 Neighboring gene PTPRS antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5225323-5225942 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5225943-5226561 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5247733-5247924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5268923-5269423 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9920 Neighboring gene uncharacterized LOC105372253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5294563-5295180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5295181-5295797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5298210-5298710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5301231-5301731 Neighboring gene ribosomal protein L32 pseudogene 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5319701-5320202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5320203-5320702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13801 Neighboring gene uncharacterized LOC105372252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5338211-5338884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5364893-5365392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:5395257-5395803 Neighboring gene Sharpr-MPRA regulatory region 11104 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51701 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:5477057-5477274 Neighboring gene uncharacterized LOC124904622 Neighboring gene zinc and ring finger 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas. Li Y, et al. Cancer Lett, 2024 Sep 1. PMID 39094827
    2. Interaction of receptor type of protein tyrosine phosphatase sigma (RPTPσ) with a glycosaminoglycan library. Tadai K, et al. J Biochem, 2018 Jul 1. PMID 29420785
    3. Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Morris LG, et al. Proc Natl Acad Sci U S A, 2011 Nov 22. PMID 22065749, Free PMC Article
    4. Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma. Zhang G, et al. Histol Histopathol, 2018 Nov. PMID 29745967
    5. PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation. Davis TB, et al. Sci Rep, 2018 Jun 18. PMID 29915291, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas.
      Title: Reduced PTPRS expression promotes epithelial-mesenchymal transition of Schwann cells in NF1-related plexiform neurofibromas.
    2. PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer's disease.
      Title: PTPRS is a novel marker for early Tau pathology and synaptic integrity in Alzheimer's disease.
    3. High expression of protein tyrosine phosphatase receptor S (PTPRS) is an independent prognostic marker for cholangiocarcinoma.
      Title: High expression of protein tyrosine phosphatase receptor S (PTPRS) is an independent prognostic marker for cholangiocarcinoma.
    4. Identification of PTPRsigma-interacting proteins by proximity-labelling assay.
      Title: Identification of PTPRσ-interacting proteins by proximity-labelling assay.
    5. High PTPRS expression is associated with hepatocellular carcinoma progression.
      Title: BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis.
    6. PTPRS modulates ERK phosphorylation and subsequent translocation to the nucleus.
      Title: PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation.
    7. loss of PTPRS expression may predict an aggressive clinical course in ESCC patients. PTPRS may function as a tumor suppressor and play an important role in esophageal squamous cell carcinoma growth and metastasis
      Title: Expression and clinical relations of protein tyrosine phosphatase receptor type S in esophageal squamous cell carcinoma.
    8. Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity.
      Title: PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis.
    9. interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library
      Title: Interaction of receptor type of protein tyrosine phosphatase sigma (RPTPσ) with a glycosaminoglycan library.
    10. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis.
      Title: Structural basis for extracellular cis and trans RPTPσ signal competition in synaptogenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRS PubMed
    Knockdown of protein tyrosine phosphatase, receptor type, Sigma (PTPRS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chondroitin sulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heparan sulfate proteoglycan binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables heparin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of axon regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of collateral sprouting ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interferon-alpha production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interferon-beta production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of toll-like receptor 9 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-tyrosine dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic density assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic membrane adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic membrane adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic membrane adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trans-synaptic signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynaptic density membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase S
    Names
    protein tyrosine phosphatase PTPsigma
    receptor-type tyrosine-protein phosphatase sigma
    NP_001380940.1
    NP_001380941.1
    NP_001380942.1
    NP_002841.3
    NP_570923.2
    NP_570924.2
    NP_570925.2
    XP_005259657.1
    XP_005259664.1
    XP_005259667.1
    XP_011526460.1
    XP_016882554.1
    XP_016882555.1
    XP_016882556.1
    XP_016882557.1
    XP_016882558.1
    XP_016882559.1
    XP_016882560.1
    XP_016882561.1
    XP_016882562.1
    XP_016882563.1
    XP_016882564.1
    XP_047295111.1
    XP_047295112.1
    XP_047295113.1
    XP_047295114.1
    XP_047295115.1
    XP_047295116.1
    XP_047295117.1
    XP_047295118.1
    XP_047295119.1
    XP_047295120.1
    XP_047295121.1
    XP_047295122.1
    XP_047295123.1
    XP_054177576.1
    XP_054177577.1
    XP_054177578.1
    XP_054177579.1
    XP_054177580.1
    XP_054177581.1
    XP_054177582.1
    XP_054177583.1
    XP_054177584.1
    XP_054177585.1
    XP_054177586.1
    XP_054177587.1
    XP_054177588.1
    XP_054177589.1
    XP_054177590.1
    XP_054177591.1
    XP_054177592.1
    XP_054177593.1
    XP_054177594.1
    XP_054177595.1
    XP_054177596.1
    XP_054177597.1
    XP_054177598.1
    XP_054177599.1
    XP_054177600.1
    XP_054177601.1
    XP_054177602.1
    XP_054177603.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033964.1 RefSeqGene

      Range
      4992..140296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394011.1 → NP_001380940.1  receptor-type tyrosine-protein phosphatase S isoform 5 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005335, AC005338, AC005788, AC005790, AC118535
      Conserved Domains (7) summary
      smart00408
      Location:150 → 214
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:238 → 315
      IG; Immunoglobulin
      smart00410
      Location:39 → 124
      IG_like; Immunoglobulin like
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14625
      Location:1348 → 1629
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:1631 → 1920
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      cd00096
      Location:165 → 169
      Ig; Ig strand C [structural motif]

    2. NM_001394012.1 → NP_001380941.1  receptor-type tyrosine-protein phosphatase S isoform 6 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005335, AC005338, AC005788, AC005790, AC118535
      Conserved Domains (7) summary
      smart00408
      Location:150 → 214
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:238 → 315
      IG; Immunoglobulin
      smart00410
      Location:39 → 124
      IG_like; Immunoglobulin like
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14625
      Location:1341 → 1622
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:1624 → 1913
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      cd00096
      Location:165 → 169
      Ig; Ig strand C [structural motif]

    3. NM_001394013.1 → NP_001380942.1  receptor-type tyrosine-protein phosphatase S isoform 7 precursor

      Status: REVIEWED

      Source sequence(s)
      AC005335, AC005338, AC005788, AC005790, AC118535
      Conserved Domains (8) summary
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14625
      Location:1328 → 1609
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:1611 → 1900
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:1186 → 1285
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:33 → 36
      Ig; Ig strand A [structural motif]
      cd05738
      Location:137 → 226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:235 → 316
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    4. NM_002850.4 → NP_002841.3  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

      See identical proteins and their annotated locations for NP_002841.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
      Consensus CDS
      CCDS45930.1
      UniProtKB/Swiss-Prot
      O75255, O75870, Q13332, Q15718, Q16341, Q2M3R7
      Related
      ENSP00000262963.8, ENST00000262963.11
      Conserved Domains (8) summary
      cd05738
      Location:152 → 235
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:259 → 327
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1392 → 1647
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:141 → 234
      IG_like; Immunoglobulin like
      cd00047
      Location:1418 → 1647
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:332 → 421
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32 → 120
      Ig; Immunoglobulin domain

    5. NM_130853.3 → NP_570923.2  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

      See identical proteins and their annotated locations for NP_570923.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC005335, AC118535, BC029496, BC104812
      Consensus CDS
      CCDS12139.1
      UniProtKB/TrEMBL
      G8JL96
      Related
      ENSP00000467398.1, ENST00000592099.5
      Conserved Domains (8) summary
      cd05738
      Location:152 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246 → 314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:945 → 1200
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:141 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:971 → 1200
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32 → 120
      Ig; Immunoglobulin domain

    6. NM_130854.3 → NP_570924.2  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

      See identical proteins and their annotated locations for NP_570924.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC005335, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
      Consensus CDS
      CCDS12140.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6, Q8NHS7
      Related
      ENSP00000465443.1, ENST00000588012.5
      Conserved Domains (8) summary
      cd05738
      Location:152 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246 → 314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1354 → 1609
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:141 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1380 → 1609
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32 → 120
      Ig; Immunoglobulin domain

    7. NM_130855.3 → NP_570925.2  receptor-type tyrosine-protein phosphatase S isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC005335, AC118535, BC029496, BC104812, U35234
      UniProtKB/TrEMBL
      G8JL96
      Conserved Domains (8) summary
      cd05738
      Location:152 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250 → 318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:949 → 1204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:141 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:975 → 1204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323 → 412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32 → 120
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      5205508..5340812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439166.1 → XP_047295122.1  receptor-type tyrosine-protein phosphatase S isoform X19

      UniProtKB/TrEMBL
      G8JL96

    2. XM_047439164.1 → XP_047295120.1  receptor-type tyrosine-protein phosphatase S isoform X17

      UniProtKB/TrEMBL
      G8JL96

    3. XM_047439162.1 → XP_047295118.1  receptor-type tyrosine-protein phosphatase S isoform X16

      UniProtKB/TrEMBL
      G8JL96

    4. XM_047439161.1 → XP_047295117.1  receptor-type tyrosine-protein phosphatase S isoform X9

    5. XM_047439155.1 → XP_047295111.1  receptor-type tyrosine-protein phosphatase S isoform X3

    6. XM_017027066.2 → XP_016882555.1  receptor-type tyrosine-protein phosphatase S isoform X1

      UniProtKB/Swiss-Prot
      Q13332

    7. XM_005259610.2 → XP_005259667.1  receptor-type tyrosine-protein phosphatase S isoform X19

      UniProtKB/TrEMBL
      G8JL96
      Conserved Domains (8) summary
      cd05738
      Location:152 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246 → 314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:941 → 1196
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:141 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:967 → 1196
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32 → 120
      Ig; Immunoglobulin domain

    8. XM_047439163.1 → XP_047295119.1  receptor-type tyrosine-protein phosphatase S isoform X16

      UniProtKB/TrEMBL
      G8JL96

    9. XM_005259607.3 → XP_005259664.1  receptor-type tyrosine-protein phosphatase S isoform X12

      Conserved Domains (8) summary
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd14625
      Location:1328 → 1609
      R-PTPc-S-1; catalytic domain of receptor-type tyrosine-protein phosphatase S, repeat 1
      cd14627
      Location:1611 → 1900
      R-PTP-S-2; PTP-like domain of receptor-type tyrosine-protein phosphatase S, repeat 2
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      pfam18861
      Location:1186 → 1285
      PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
      cd00096
      Location:33 → 36
      Ig; Ig strand A [structural motif]
      cd05738
      Location:137 → 226
      IgI_2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F; member of the I-set of IgSF domains
      cd05739
      Location:235 → 316
      IgI_3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F (also known as LAR), type IIa; member of the I-set of IgSF domains

    10. XM_047439160.1 → XP_047295116.1  receptor-type tyrosine-protein phosphatase S isoform X9

    11. XM_047439159.1 → XP_047295115.1  receptor-type tyrosine-protein phosphatase S isoform X7

    12. XM_047439157.1 → XP_047295113.1  receptor-type tyrosine-protein phosphatase S isoform X4

    13. XM_005259600.3 → XP_005259657.1  receptor-type tyrosine-protein phosphatase S isoform X3

      See identical proteins and their annotated locations for XP_005259657.1

      Conserved Domains (8) summary
      cd05738
      Location:152 → 226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246 → 314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00194
      Location:1379 → 1634
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:141 → 225
      IG_like; Immunoglobulin like
      cd00047
      Location:1405 → 1634
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319 → 408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33 → 124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32 → 120
      Ig; Immunoglobulin domain

    14. XM_047439165.1 → XP_047295121.1  receptor-type tyrosine-protein phosphatase S isoform X18

      UniProtKB/TrEMBL
      G8JL96

    15. XM_017027075.2 → XP_016882564.1  receptor-type tyrosine-protein phosphatase S isoform X15

      UniProtKB/TrEMBL
      G8JL96

    16. XM_017027074.2 → XP_016882563.1  receptor-type tyrosine-protein phosphatase S isoform X14

      UniProtKB/TrEMBL
      G8JL96

    17. XM_017027072.2 → XP_016882561.1  receptor-type tyrosine-protein phosphatase S isoform X11

    18. XM_047439158.1 → XP_047295114.1  receptor-type tyrosine-protein phosphatase S isoform X6

    19. XM_017027069.2 → XP_016882558.1  receptor-type tyrosine-protein phosphatase S isoform X5

    20. XM_017027071.2 → XP_016882560.1  receptor-type tyrosine-protein phosphatase S isoform X10

    21. XM_017027068.2 → XP_016882557.1  receptor-type tyrosine-protein phosphatase S isoform X2

    22. XM_017027070.2 → XP_016882559.1  receptor-type tyrosine-protein phosphatase S isoform X8

    23. XM_017027065.2 → XP_016882554.1  receptor-type tyrosine-protein phosphatase S isoform X1

      UniProtKB/Swiss-Prot
      Q13332

    24. XM_047439156.1 → XP_047295112.1  receptor-type tyrosine-protein phosphatase S isoform X3

    25. XM_017027067.2 → XP_016882556.1  receptor-type tyrosine-protein phosphatase S isoform X1

      UniProtKB/Swiss-Prot
      Q13332

    26. XM_017027073.2 → XP_016882562.1  receptor-type tyrosine-protein phosphatase S isoform X13

    27. XM_047439167.1 → XP_047295123.1  receptor-type tyrosine-protein phosphatase S isoform X21

    28. XM_011528158.3 → XP_011526460.1  receptor-type tyrosine-protein phosphatase S isoform X20

      Conserved Domains (3) summary
      smart00194
      Location:601 → 856
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:627 → 856
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:141 → 238
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      5192102..5327425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321626.1 → XP_054177601.1  receptor-type tyrosine-protein phosphatase S isoform X19

      UniProtKB/TrEMBL
      G8JL96

    2. XM_054321623.1 → XP_054177598.1  receptor-type tyrosine-protein phosphatase S isoform X17

      UniProtKB/TrEMBL
      G8JL96

    3. XM_054321621.1 → XP_054177596.1  receptor-type tyrosine-protein phosphatase S isoform X16

      UniProtKB/TrEMBL
      G8JL96

    4. XM_054321614.1 → XP_054177589.1  receptor-type tyrosine-protein phosphatase S isoform X9

    5. XM_054321606.1 → XP_054177581.1  receptor-type tyrosine-protein phosphatase S isoform X3

    6. XM_054321601.1 → XP_054177576.1  receptor-type tyrosine-protein phosphatase S isoform X1

    7. XM_054321622.1 → XP_054177597.1  receptor-type tyrosine-protein phosphatase S isoform X16

      UniProtKB/TrEMBL
      G8JL96

    8. XM_054321602.1 → XP_054177577.1  receptor-type tyrosine-protein phosphatase S isoform X1

    9. XM_054321624.1 → XP_054177599.1  receptor-type tyrosine-protein phosphatase S isoform X18

      UniProtKB/TrEMBL
      G8JL96

    10. XM_054321620.1 → XP_054177595.1  receptor-type tyrosine-protein phosphatase S isoform X15

      UniProtKB/TrEMBL
      G8JL96

    11. XM_054321619.1 → XP_054177594.1  receptor-type tyrosine-protein phosphatase S isoform X14

      UniProtKB/TrEMBL
      G8JL96

    12. XM_054321616.1 → XP_054177591.1  receptor-type tyrosine-protein phosphatase S isoform X11

    13. XM_054321610.1 → XP_054177585.1  receptor-type tyrosine-protein phosphatase S isoform X6

    14. XM_054321609.1 → XP_054177584.1  receptor-type tyrosine-protein phosphatase S isoform X5

    15. XM_054321615.1 → XP_054177590.1  receptor-type tyrosine-protein phosphatase S isoform X10

    16. XM_054321604.1 → XP_054177579.1  receptor-type tyrosine-protein phosphatase S isoform X2

    17. XM_054321612.1 → XP_054177587.1  receptor-type tyrosine-protein phosphatase S isoform X8

    18. XM_054321625.1 → XP_054177600.1  receptor-type tyrosine-protein phosphatase S isoform X19

      UniProtKB/TrEMBL
      G8JL96

    19. XM_054321617.1 → XP_054177592.1  receptor-type tyrosine-protein phosphatase S isoform X12

    20. XM_054321613.1 → XP_054177588.1  receptor-type tyrosine-protein phosphatase S isoform X9

    21. XM_054321611.1 → XP_054177586.1  receptor-type tyrosine-protein phosphatase S isoform X7

    22. XM_054321608.1 → XP_054177583.1  receptor-type tyrosine-protein phosphatase S isoform X4

    23. XM_054321605.1 → XP_054177580.1  receptor-type tyrosine-protein phosphatase S isoform X3

    24. XM_054321607.1 → XP_054177582.1  receptor-type tyrosine-protein phosphatase S isoform X3

    25. XM_054321603.1 → XP_054177578.1  receptor-type tyrosine-protein phosphatase S isoform X1

    26. XM_054321618.1 → XP_054177593.1  receptor-type tyrosine-protein phosphatase S isoform X13

    27. XM_054321628.1 → XP_054177603.1  receptor-type tyrosine-protein phosphatase S isoform X21

    28. XM_054321627.1 → XP_054177602.1  receptor-type tyrosine-protein phosphatase S isoform X20

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13332.3 GenPept UniProtKB/Swiss-Prot:Q13332

    Gene LinkOut

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