Atrip ATR interacting protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atripprovided by MGI
Official Full Name: ATR interacting proteinprovided by MGI
Primary source: MGI:MGI:1925349
See related: Ensembl:ENSMUSG00000025646 AllianceGenome:MGI:1925349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6620401K05Rik
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in DNA repair. Part of ATR-ATRIP complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; eye; and genitourinary system. Used to study Seckel syndrome. Orthologous to human ATRIP (ATR interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 11.5), thymus adult (RPKM 7.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.63 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108888815..108903192, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (109059747..109074124, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.
Title: Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Readthrough Gm53191

Readthrough gene: Gm53191, Included gene: Trex1

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of ATR-ATRIP complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ATR-ATRIP complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: ATR-interacting protein

Names: ATM and Rad3 related interacting protein

NP_766362.2

EC 3.1.11.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172774.3 → NP_766362.2 ATR-interacting protein

See identical proteins and their annotated locations for NP_766362.2

Status: VALIDATED

Source sequence(s)

AC140383, AK031257, BB649616

Consensus CDS

CCDS23545.1

UniProtKB/Swiss-Prot

E9QLS8, Q8BMG1

UniProtKB/TrEMBL

E9Q6L5

Related

ENSMUSP00000044831.3, ENSMUST00000045011.9

Conserved Domains (1) summary

cl09111
Location:117 → 205

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...